Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders

M. D. Hettwer (), S. Larivière, B. Y. Park, O. A. Heuvel, L. Schmaal, O. A. Andreassen, C. R. K. Ching, M. Hoogman, J. Buitelaar, D. Rooij, D. J. Veltman, D. J. Stein, B. Franke, T. G. M. Erp, N. Jahanshad, P. M. Thompson, S. I. Thomopoulos, R. A. I. Bethlehem, B. C. Bernhardt, S. B. Eickhoff and S. L. Valk ()
Additional contact information
M. D. Hettwer: Heinrich Heine University Düsseldorf
S. Larivière: Montreal Neurological Institute, McGill University
B. Y. Park: Montreal Neurological Institute, McGill University
O. A. Heuvel: Vrije Universiteit Amsterdam, Department of Anatomy and Neuroscience and Psychiatry, Amsterdam Neuroscience
L. Schmaal: The University of Melbourne
O. A. Andreassen: University of Oslo and Oslo University Hospital
C. R. K. Ching: Keck School of Medicine, University of Southern California
M. Hoogman: Radboud University Medical Center
J. Buitelaar: Radboud University Medical Center
D. Rooij: Radboud University Medical Center
D. J. Veltman: Vrije Universiteit Amsterdam, Department of Anatomy and Neuroscience and Psychiatry, Amsterdam Neuroscience
D. J. Stein: University of Cape Town
B. Franke: Radboud University Medical Center
T. G. M. Erp: University of California Irvine, Irvine Hall
N. Jahanshad: Keck School of Medicine, University of Southern California
P. M. Thompson: Keck School of Medicine, University of Southern California
S. I. Thomopoulos: Keck School of Medicine, University of Southern California
R. A. I. Bethlehem: University of Cambridge
B. C. Bernhardt: Montreal Neurological Institute, McGill University
S. B. Eickhoff: Heinrich Heine University Düsseldorf
S. L. Valk: Heinrich Heine University Düsseldorf

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract Neuropsychiatric disorders are increasingly conceptualized as overlapping spectra sharing multi-level neurobiological alterations. However, whether transdiagnostic cortical alterations covary in a biologically meaningful way is currently unknown. Here, we studied co-alteration networks across six neurodevelopmental and psychiatric disorders, reflecting pathological structural covariance. In 12,024 patients and 18,969 controls from the ENIGMA consortium, we observed that co-alteration patterns followed normative connectome organization and were anchored to prefrontal and temporal disease epicenters. Manifold learning revealed frontal-to-temporal and sensory/limbic-to-occipitoparietal transdiagnostic gradients, differentiating shared illness effects on cortical thickness along these axes. The principal gradient aligned with a normative cortical thickness covariance gradient and established a transcriptomic link to cortico-cerebello-thalamic circuits. Moreover, transdiagnostic gradients segregated functional networks involved in basic sensory, attentional/perceptual, and domain-general cognitive processes, and distinguished between regional cytoarchitectonic profiles. Together, our findings indicate that shared illness effects occur in a synchronized fashion and along multiple levels of hierarchical cortical organization.

Date: 2022
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DOI: 10.1038/s41467-022-34367-6

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