Lipidomic signatures align with inflammatory patterns and outcomes in critical illness

Junru Wu, Anthony Cyr, Danielle S. Gruen, Tyler C. Lovelace, Panayiotis V. Benos, Jishnu Das, Upendra K. Kar, Tianmeng Chen, Francis X. Guyette, Mark H. Yazer, Brian J. Daley, Richard S. Miller, Brian G. Harbrecht, Jeffrey A. Claridge, Herb A. Phelan, Brian S. Zuckerbraun, Matthew D. Neal, Pär I. Johansson, Jakob Stensballe, Rami A. Namas, Yoram Vodovotz, Jason L. Sperry () and Timothy R. Billiar ()
Additional contact information
Junru Wu: University of Pittsburgh
Anthony Cyr: University of Pittsburgh
Danielle S. Gruen: University of Pittsburgh
Tyler C. Lovelace: University of Pittsburgh
Panayiotis V. Benos: University of Pittsburgh
Upendra K. Kar: University of Pittsburgh
Tianmeng Chen: University of Pittsburgh
Francis X. Guyette: University of Pittsburgh
Mark H. Yazer: The Institute for Transfusion Medicine
Brian J. Daley: University of Tennessee Health Science Center
Richard S. Miller: Vanderbilt University Medical Center
Brian G. Harbrecht: University of Louisville
Jeffrey A. Claridge: Case Western Reserve University
Herb A. Phelan: University of Texas Southwestern
Brian S. Zuckerbraun: University of Pittsburgh
Matthew D. Neal: University of Pittsburgh
Pär I. Johansson: Copenhagen University Hospital
Jakob Stensballe: Copenhagen University Hospital
Rami A. Namas: University of Pittsburgh
Yoram Vodovotz: University of Pittsburgh
Jason L. Sperry: University of Pittsburgh
Timothy R. Billiar: University of Pittsburgh

Nature Communications, 2022, vol. 13, issue 1, 1-18

Abstract: Abstract Alterations in lipid metabolism have the potential to be markers as well as drivers of pathobiology of acute critical illness. Here, we took advantage of the temporal precision offered by trauma as a common cause of critical illness to identify the dynamic patterns in the circulating lipidome in critically ill humans. The major findings include an early loss of all classes of circulating lipids followed by a delayed and selective lipogenesis in patients destined to remain critically ill. The previously reported survival benefit of early thawed plasma administration was associated with preserved lipid levels that related to favorable changes in coagulation and inflammation biomarkers in causal modelling. Phosphatidylethanolamines (PE) were elevated in patients with persistent critical illness and PE levels were prognostic for worse outcomes not only in trauma but also severe COVID-19 patients. Here we show selective rise in systemic PE as a common prognostic feature of critical illness.

Date: 2022
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DOI: 10.1038/s41467-022-34420-4

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