Multi-omics signatures of the human early life exposome

Léa Maitre, Mariona Bustamante, Carles Hernández-Ferrer, Denise Thiel, Chung-Ho E. Lau, Alexandros P. Siskos, Marta Vives-Usano, Carlos Ruiz-Arenas, Dolors Pelegrí-Sisó, Oliver Robinson, Dan Mason, John Wright, Solène Cadiou, Rémy Slama, Barbara Heude, Maribel Casas, Jordi Sunyer, Eleni Z. Papadopoulou, Kristine B. Gutzkow, Sandra Andrusaityte, Regina Grazuleviciene, Marina Vafeiadi, Leda Chatzi, Amrit K. Sakhi, Cathrine Thomsen, Ibon Tamayo, Mark Nieuwenhuijsen, Jose Urquiza, Eva Borràs, Eduard Sabidó, Inés Quintela, Ángel Carracedo, Xavier Estivill, Muireann Coen, Juan R. González, Hector C. Keun and Martine Vrijheid ()
Additional contact information
Léa Maitre: Institute for Global Health (ISGlobal)
Mariona Bustamante: Institute for Global Health (ISGlobal)
Carles Hernández-Ferrer: Institute for Global Health (ISGlobal)
Denise Thiel: Imperial College London
Chung-Ho E. Lau: Imperial College London
Alexandros P. Siskos: Imperial College London
Marta Vives-Usano: Institute for Global Health (ISGlobal)
Carlos Ruiz-Arenas: Institute for Global Health (ISGlobal)
Dolors Pelegrí-Sisó: Institute for Global Health (ISGlobal)
Oliver Robinson: Imperial College London
Dan Mason: Bradford Teaching Hospitals NHS Foundation Trust
John Wright: Bradford Teaching Hospitals NHS Foundation Trust
Solène Cadiou: Inserm, CNRS, Université Grenoble Alpes
Rémy Slama: Inserm, CNRS, Université Grenoble Alpes
Barbara Heude: Inserm, Université de Paris
Maribel Casas: Institute for Global Health (ISGlobal)
Jordi Sunyer: Institute for Global Health (ISGlobal)
Eleni Z. Papadopoulou: Norwegian Institute of Public Health
Kristine B. Gutzkow: Norwegian Institute of Public Health
Sandra Andrusaityte: Vytautas Magnus University
Regina Grazuleviciene: Vytautas Magnus University
Marina Vafeiadi: Faculty of Medicine, University of Crete
Leda Chatzi: University of Southern California
Amrit K. Sakhi: Norwegian Institute of Public Health
Cathrine Thomsen: Norwegian Institute of Public Health
Ibon Tamayo: CIMA-University of Navarra
Mark Nieuwenhuijsen: Institute for Global Health (ISGlobal)
Jose Urquiza: Institute for Global Health (ISGlobal)
Eva Borràs: Universitat Pompeu Fabra (UPF)
Eduard Sabidó: Universitat Pompeu Fabra (UPF)
Inés Quintela: University of Santiago de Compostela, CIMUS
Ángel Carracedo: University of Santiago de Compostela, CIMUS
Xavier Estivill: Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology
Muireann Coen: Imperial College London
Juan R. González: Institute for Global Health (ISGlobal)
Hector C. Keun: Imperial College London
Martine Vrijheid: Institute for Global Health (ISGlobal)

Nature Communications, 2022, vol. 13, issue 1, 1-18

Abstract: Abstract Environmental exposures during early life play a critical role in life-course health, yet the molecular phenotypes underlying environmental effects on health are poorly understood. In the Human Early Life Exposome (HELIX) project, a multi-centre cohort of 1301 mother-child pairs, we associate individual exposomes consisting of >100 chemical, outdoor, social and lifestyle exposures assessed in pregnancy and childhood, with multi-omics profiles (methylome, transcriptome, proteins and metabolites) in childhood. We identify 1170 associations, 249 in pregnancy and 921 in childhood, which reveal potential biological responses and sources of exposure. Pregnancy exposures, including maternal smoking, cadmium and molybdenum, are predominantly associated with child DNA methylation changes. In contrast, childhood exposures are associated with features across all omics layers, most frequently the serum metabolome, revealing signatures for diet, toxic chemical compounds, essential trace elements, and weather conditions, among others. Our comprehensive and unique resource of all associations ( https://helixomics.isglobal.org/ ) will serve to guide future investigation into the biological imprints of the early life exposome.

Date: 2022
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DOI: 10.1038/s41467-022-34422-2

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