Bidirectional and parallel relationships in macaque face circuit revealed by fMRI and causal pharmacological inactivation

Ning Liu (), Marlene Behrmann, Janita N. Turchi, Galia Avidan, Fadila Hadj-Bouziane and Leslie G. Ungerleider
Additional contact information
Ning Liu: NIMH, NIH
Marlene Behrmann: University of Pittsburgh
Janita N. Turchi: NIMH, NIH
Galia Avidan: Ben-Gurion University of the Negev
Fadila Hadj-Bouziane: NIMH, NIH
Leslie G. Ungerleider: NIMH, NIH

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract Although the presence of face patches in primate inferotemporal (IT) cortex is well established, the functional and causal relationships among these patches remain elusive. In two monkeys, muscimol was infused sequentially into each patch or pair of patches to assess their respective influence on the remaining IT face network and the amygdala, as determined using fMRI. The results revealed that anterior face patches required input from middle face patches for their responses to both faces and objects, while the face selectivity in middle face patches arose, in part, from top-down input from anterior face patches. Moreover, we uncovered a parallel fundal-lateral functional organization in the IT face network, supporting dual routes (dorsal-ventral) in face processing within IT cortex as well as between IT cortex and the amygdala. Our findings of the causal relationship among the face patches demonstrate that the IT face circuit is organized into multiple functional compartments.

Date: 2022
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DOI: 10.1038/s41467-022-34451-x

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