Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo

Linda Judák, Balázs Chiovini, Gábor Juhász, Dénes Pálfi, Zsolt Mezriczky, Zoltán Szadai, Gergely Katona, Benedek Szmola, Katalin Ócsai, Bernadett Martinecz, Anna Mihály, Ádám Dénes, Bálint Kerekes, Áron Szepesi, Gergely Szalay, István Ulbert, Zoltán Mucsi, Botond Roska and Balázs Rózsa ()
Additional contact information
Linda Judák: Institute of Experimental Medicine
Balázs Chiovini: Institute of Experimental Medicine
Gábor Juhász: Pázmány Péter University
Dénes Pálfi: Institute of Experimental Medicine
Zsolt Mezriczky: Pázmány Péter University
Zoltán Szadai: Institute of Experimental Medicine
Gergely Katona: Pázmány Péter University
Benedek Szmola: Pázmány Péter University
Katalin Ócsai: Pázmány Péter University
Bernadett Martinecz: Institute of Experimental Medicine
Anna Mihály: Pázmány Péter University
Ádám Dénes: Institute of Experimental Medicine
Bálint Kerekes: Pázmány Péter University
Áron Szepesi: Institute of Experimental Medicine
Gergely Szalay: Institute of Experimental Medicine
István Ulbert: Pázmány Péter University
Zoltán Mucsi: BrainVisionCenter
Botond Roska: BrainVisionCenter
Balázs Rózsa: Institute of Experimental Medicine

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Neuronal plasticity has been shown to be causally linked to coincidence detection through dendritic spikes (dSpikes). We demonstrate the existence of SPW-R-associated, branch-specific, local dSpikes and their computational role in basal dendrites of hippocampal PV+ interneurons in awake animals. To measure the entire dendritic arbor of long thin dendrites during SPW-Rs, we used fast 3D acousto-optical imaging through an eccentric deep-brain adapter and ipsilateral local field potential recording. The regenerative calcium spike started at variable, NMDA-AMPA-dependent, hot spots and propagated in both direction with a high amplitude beyond a critical distance threshold (~150 µm) involving voltage-gated calcium channels. A supralinear dendritic summation emerged during SPW-R doublets when two successive SPW-R events coincide within a short temporal window (~150 ms), e.g., during more complex association tasks, and generated large dSpikes with an about 2.5-3-fold amplitude increase which propagated down to the soma. Our results suggest that these doublet-associated dSpikes can work as a dendritic-level temporal and spatial coincidence detector during SPW-R-related network computation in awake mice.

Date: 2022
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DOI: 10.1038/s41467-022-34520-1

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