Hyperbolic material enhanced scattering nanoscopy for label-free super-resolution imaging

Yeon Ui Lee, Shilong Li, G. Bimananda M. Wisna, Junxiang Zhao, Yuan Zeng, Andrea R. Tao and Zhaowei Liu ()
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Yeon Ui Lee: University of California, San Diego
Shilong Li: University of California, San Diego
G. Bimananda M. Wisna: University of California, San Diego
Junxiang Zhao: University of California, San Diego
Yuan Zeng: University of California, San Diego
Andrea R. Tao: University of California, San Diego
Zhaowei Liu: University of California, San Diego

Nature Communications, 2022, vol. 13, issue 1, 1-8

Abstract: Abstract Fluorescence super-resolution microscopy has, over the last two decades, been extensively developed to access deep-subwavelength nanoscales optically. Label-free super-resolution technologies however have only achieved a slight improvement compared to the diffraction limit. In this context, we demonstrate a label-free imaging method, i.e., hyperbolic material enhanced scattering (HMES) nanoscopy, which breaks the diffraction limit by tailoring the light-matter interaction between the specimens and a hyperbolic material substrate. By exciting the highly confined evanescent hyperbolic polariton modes with dark-field detection, HMES nanoscopy successfully shows a high-contrast scattering image with a spatial resolution around 80 nm. Considering the wavelength at 532 nm and detection optics with a 0.6 numerical aperture (NA) objective lens, this value represents a 5.5-fold resolution improvement beyond the diffraction limit. HMES provides capabilities for super-resolution imaging where fluorescence is not available or challenging to apply.

Date: 2022
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DOI: 10.1038/s41467-022-34553-6

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