Independently evolved viral effectors convergently suppress DELLA protein SLR1-mediated broad-spectrum antiviral immunity in rice

Lulu Li, Hehong Zhang, Zihang Yang, Chen Wang, Shanshan Li, Chen Cao, Tongsong Yao, Zhongyan Wei, Yanjun Li, Jianping Chen () and Zongtao Sun ()
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Lulu Li: Nanjing Agricultural University
Hehong Zhang: Ningbo University
Zihang Yang: Ningbo University
Chen Wang: Nanjing Agricultural University
Shanshan Li: Nanjing Agricultural University
Chen Cao: Ningbo University
Tongsong Yao: Nanjing Agricultural University
Zhongyan Wei: Ningbo University
Yanjun Li: Ningbo University
Jianping Chen: Nanjing Agricultural University
Zongtao Sun: Ningbo University

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract Plant viruses adopt diverse virulence strategies to inhibit host antiviral defense. However, general antiviral defense directly targeted by different types of plant viruses have rarely been studied. Here, we show that the single rice DELLA protein, SLENDER RICE 1 (SLR1), a master negative regulator in Gibberellin (GA) signaling pathway, is targeted by several different viral effectors for facilitating viral infection. Viral proteins encoded by different types of rice viruses all directly trigger the rapid degradation of SLR1 by promoting association with the GA receptor OsGID1. SLR1-mediated broad-spectrum resistance was subverted by these independently evolved viral proteins, which all interrupted the functional crosstalk between SLR1 and jasmonic acid (JA) signaling. This decline of JA antiviral further created the advantage of viral infection. Our study reveals a common viral counter-defense strategy in which different types of viruses convergently target SLR1-mediated broad-spectrum resistance to benefit viral infection in the monocotyledonous crop rice.

Date: 2022
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DOI: 10.1038/s41467-022-34649-z

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