Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer’s disease

Camila Fernández Zapata, Ginevra Giacomello, Eike J. Spruth, Jinte Middeldorp, Gerardina Gallaccio, Adeline Dehlinger, Claudia Dames, Julia K. H. Leman, Roland E. van Dijk, Andreas Meisel, Stephan Schlickeiser, Desiree Kunkel, Elly M. Hol, Friedemann Paul, Maria Kristina Parr, Josef Priller () and Chotima Böttcher ()
Additional contact information
Camila Fernández Zapata: a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin
Ginevra Giacomello: Freie Universität Berlin
Eike J. Spruth: Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
Jinte Middeldorp: Utrecht University
Gerardina Gallaccio: a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin
Adeline Dehlinger: a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin
Claudia Dames: Charité-Universitätsmedizin Berlin
Julia K. H. Leman: Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
Roland E. van Dijk: Utrecht University
Andreas Meisel: Charité-Universitätsmedizin Berlin
Stephan Schlickeiser: Institute of Medical Immunology, BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité - Universitätsmedizin Berlin
Desiree Kunkel: Flow & Mass Cytometry Core Facility, Berlin Institute of Health at Charité - Universitätsmedizin Berlin
Elly M. Hol: Utrecht University
Friedemann Paul: a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin
Maria Kristina Parr: Freie Universität Berlin
Josef Priller: Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
Chotima Böttcher: a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin

Nature Communications, 2022, vol. 13, issue 1, 1-18

Abstract: Abstract Myeloid cells are suggested as an important player in Alzheimer´s disease (AD). However, its continuum of phenotypic and functional changes across different body compartments and their use as a biomarker in AD remains elusive. Here, we perform multiple state-of-the-art analyses to phenotypically and metabolically characterize immune cells between peripheral blood (n = 117), cerebrospinal fluid (CSF, n = 117), choroid plexus (CP, n = 13) and brain parenchyma (n = 13). We find that CSF cells increase expression of markers involved in inflammation, phagocytosis, and metabolism. Changes in phenotype of myeloid cells from AD patients are more pronounced in CP and brain parenchyma and upon in vitro stimulation, suggesting that AD-myeloid cells are more vulnerable to environmental changes. Our findings underscore the importance of myeloid cells in AD and the detailed characterization across body compartments may serve as a resource for future studies focusing on the assessment of these cells as biomarkers in AD.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34719-2

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DOI: 10.1038/s41467-022-34719-2

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