REM sleep is associated with distinct global cortical dynamics and controlled by occipital cortex

Ziyue Wang, Xiang Fei, Xiaotong Liu, Yanjie Wang, Yue Hu, Wanling Peng, Ying-wei Wang, Siyu Zhang () and Min Xu ()
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Ziyue Wang: Chinese Academy of Sciences
Xiang Fei: Chinese Academy of Sciences
Xiaotong Liu: Chinese Academy of Sciences
Yanjie Wang: Chinese Academy of Sciences
Yue Hu: Chinese Academy of Sciences
Wanling Peng: Chinese Academy of Sciences
Ying-wei Wang: Fudan University
Siyu Zhang: Shanghai Jiao Tong University School of Medicine
Min Xu: Chinese Academy of Sciences

Nature Communications, 2022, vol. 13, issue 1, 1-17

Abstract: Abstract The cerebral cortex is spontaneously active during sleep, yet it is unclear how this global cortical activity is spatiotemporally organized, and whether such activity not only reflects sleep states but also contributes to sleep state switching. Here we report that cortex-wide calcium imaging in mice revealed distinct sleep stage-dependent spatiotemporal patterns of global cortical activity, and modulation of such patterns could regulate sleep state switching. In particular, elevated activation in the occipital cortical regions (including the retrosplenial cortex and visual areas) became dominant during rapid-eye-movement (REM) sleep. Furthermore, such pontogeniculooccipital (PGO) wave-like activity was associated with transitions to REM sleep, and optogenetic inhibition of occipital activity strongly promoted deep sleep by suppressing the NREM-to-REM transition. Thus, whereas subcortical networks are critical for initiating and maintaining sleep and wakefulness states, distinct global cortical activity also plays an active role in controlling sleep states.

Date: 2022
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DOI: 10.1038/s41467-022-34720-9

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