Biomimetic electrodynamic nanoparticles comprising ginger-derived extracellular vesicles for synergistic anti-infective therapy

Zhuangzhuang Qiao, Kai Zhang, Jin Liu, Daojian Cheng, Bingran Yu, Nana Zhao () and Fu-Jian Xu ()
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Zhuangzhuang Qiao: Beijing University of Chemical Technology
Kai Zhang: Beijing University of Chemical Technology
Jin Liu: Beijing University of Chemical Technology
Daojian Cheng: Beijing University of Chemical Technology
Bingran Yu: Beijing University of Chemical Technology
Nana Zhao: Beijing University of Chemical Technology
Fu-Jian Xu: Beijing University of Chemical Technology

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract Nanotechnology enlightens promising antibacterial strategies while the complex in vivo infection environment poses a great challenge to the rational design of nanoplatforms for safe and effective anti-infective therapy. Herein, a biomimetic nanoplatform (EV-Pd-Pt) integrating electrodynamic Pd-Pt nanosheets and natural ginger-derived extracellular vesicles (EVs) is proposed. The introduction of ginger-derived EVs greatly endows EV-Pd-Pt with prolonged blood circulation without immune clearance, as well as accumulation at infection sites. More interestingly, EV-Pd-Pt can enter the interior of bacteria in an EV lipid-dependent manner. At the same time, reactive oxygen species are sustainably generated in situ to overcome the limitations of their short lifetime and diffusion distance. Notably, EV-Pd-Pt nanoparticle-mediated electrodynamic and photothermal therapy exhibit synergistic effects. Furthermore, the desirable biocompatibility and biosafety of the proposed nanoplatform guarantee the feasibility of in vivo applications. This proof-of-concept work holds significant promise for developing biomimetic nanoparticles by exploiting their intrinsic properties for synergistic anti-infective therapy.

Date: 2022
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DOI: 10.1038/s41467-022-34883-5

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