CRY2 interacts with CIS1 to regulate thermosensory flowering via FLM alternative splicing

Zhiwei Zhao, Craig Dent, Huafeng Liang, Junqing Lv, Guandong Shang, Yawen Liu, Fan Feng, Fei Wang, Junhong Pang, Xu Li, Libang Ma, Bing Li, Sridevi Sureshkumar, Jia-Wei Wang, Sureshkumar Balasubramanian and Hongtao Liu ()
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Zhiwei Zhao: Chinese Academy of Sciences
Craig Dent: Monash University
Huafeng Liang: Chinese Academy of Sciences
Junqing Lv: Chinese Academy of Sciences
Guandong Shang: Chinese Academy of Sciences
Yawen Liu: Chinese Academy of Sciences
Fan Feng: Chinese Academy of Sciences
Fei Wang: Chinese Academy of Sciences
Junhong Pang: Chinese Academy of Sciences
Xu Li: Chinese Academy of Sciences
Libang Ma: Chinese Academy of Sciences
Bing Li: Hebei Normal University
Sridevi Sureshkumar: Monash University
Jia-Wei Wang: Chinese Academy of Sciences
Sureshkumar Balasubramanian: Monash University
Hongtao Liu: Chinese Academy of Sciences

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Cryptochromes (CRYs) are evolutionarily conserved photolyase-like photoreceptors found in almost all species, including mammals. CRYs regulate transcription by modulating the activity of several transcription factors, but whether and how they affect pre-mRNA processing are unknown. Photoperiod and temperature are closely associated seasonal cues that influence reproductive timing in plants. CRYs mediate photoperiod-responsive floral initiation, but it is largely unknown whether and how they are also involved in thermosensory flowering. We establish here that blue light and CRY2 play critical roles in thermosensory flowering in Arabidopsis thaliana by regulating RNA alternative splicing (AS) to affect protein expression and development. CRY2 INTERACTING SPLICING FACTOR 1 (CIS1) interacts with CRY2 in a blue light–dependent manner and promotes CRY2–mediated thermosensory flowering. Blue light, CRYs, and CISs affect transcriptome-wide AS profiles, including those of FLOWERING LOCUS M (FLM), which is critical for temperature modulation of flowering. Moreover, CIS1 binds to the FLM pre-mRNA to regulate its AS, while CRY2 regulates the RNA-binding activity of CIS1. Thus, blue light regulates thermosensory flowering via a CRY2–CIS1–FLM signaling pathway that links flowering responses to both light and ambient temperature.

Date: 2022
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DOI: 10.1038/s41467-022-34886-2

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