Critical Offset Magnetic PArticle SpectroScopy for rapid and highly sensitive medical point-of-care diagnostics

Patrick Vogel (), Martin Andreas Rückert, Bernhard Friedrich, Rainer Tietze, Stefan Lyer, Thomas Kampf, Thomas Hennig, Lars Dölken, Christoph Alexiou and Volker Christian Behr
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Patrick Vogel: Julius-Maximilians-University Würzburg
Martin Andreas Rückert: Julius-Maximilians-University Würzburg
Bernhard Friedrich: University Hospital Erlangen
Rainer Tietze: University Hospital Erlangen
Stefan Lyer: University Hospital Erlangen
Thomas Kampf: Julius-Maximilians-University Würzburg
Thomas Hennig: Julius-Maximilians-University Würzburg
Lars Dölken: Julius-Maximilians-University Würzburg
Christoph Alexiou: University Hospital Erlangen
Volker Christian Behr: Julius-Maximilians-University Würzburg

Nature Communications, 2022, vol. 13, issue 1, 1-9

Abstract: Abstract Magnetic nanoparticles (MNPs) have been adapted for many applications, e.g., bioassays for the detection of biomarkers such as antibodies, by controlled engineering of specific surface properties. Specific measurement of such binding states is of high interest but currently limited to highly sensitive techniques such as ELISA or flow cytometry, which are relatively inflexible, difficult to handle, expensive and time-consuming. Here we report a method named COMPASS (Critical-Offset-Magnetic-Particle-SpectroScopy), which is based on a critical offset magnetic field, enabling sensitive detection to minimal changes in mobility of MNP ensembles, e.g., resulting from SARS-CoV-2 antibodies binding to the S antigen on the surface of functionalized MNPs. With a sensitivity of 0.33 fmole/50 µl (≙7 pM) for SARS-CoV-2-S1 antibodies, measured with a low-cost portable COMPASS device, the proposed technique is competitive with respect to sensitivity while providing flexibility, robustness, and a measurement time of seconds per sample. In addition, initial results with blood serum demonstrate high specificity.

Date: 2022
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DOI: 10.1038/s41467-022-34941-y

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