Dynamics of extended-spectrum cephalosporin resistance genes in Escherichia coli from Europe and North America

Roxana Zamudio, Patrick Boerlin, Racha Beyrouthy, Jean-Yves Madec, Stefan Schwarz, Michael R. Mulvey, George G. Zhanel, Ashley Cormier, Gabhan Chalmers, Richard Bonnet, Marisa Haenni, Inga Eichhorn, Heike Kaspar, Raquel Garcia-Fierro, James L. N. Wood and Alison E. Mather ()
Additional contact information
Roxana Zamudio: Norwich Research Park
Patrick Boerlin: University of Guelph
Racha Beyrouthy: Université Clermont Auvergne
Jean-Yves Madec: Anses Laboratoire de Lyon, Université de Lyon
Stefan Schwarz: Freie Universität Berlin
Michael R. Mulvey: Public Health Agency of Canada
George G. Zhanel: University of Manitoba
Ashley Cormier: University of Guelph
Gabhan Chalmers: University of Guelph
Richard Bonnet: Université Clermont Auvergne
Marisa Haenni: Anses Laboratoire de Lyon, Université de Lyon
Inga Eichhorn: Freie Universität Berlin
Heike Kaspar: Resistance to Antibiotics Unit Monitoring of Resistance to Antibiotics, Federal Office of Consumer Protection and Food Safety
Raquel Garcia-Fierro: Anses Laboratoire de Lyon, Université de Lyon
James L. N. Wood: University of Cambridge
Alison E. Mather: Norwich Research Park

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Extended-spectrum cephalosporins (ESCs) are critically important antimicrobial agents for human and veterinary medicine. ESC resistance (ESC-R) genes have spread worldwide through plasmids and clonal expansion, yet the distribution and dynamics of ESC-R genes in different ecological compartments are poorly understood. Here we use whole genome sequence data of Enterobacterales isolates of human and animal origin from Europe and North America and identify contrasting temporal dynamics. AmpC β-lactamases were initially more dominant in North America in humans and farm animals, only later emerging in Europe. In contrast, specific extended-spectrum β-lactamases (ESBLs) were initially common in animals from Europe and later emerged in North America. This study identifies differences in the relative importance of plasmids and clonal expansion across different compartments for the spread of different ESC-R genes. Understanding the mechanisms of transmission will be critical in the design of interventions to reduce the spread of antimicrobial resistance.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-022-34970-7 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34970-7

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-34970-7

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().