Seroepidemiology of enterovirus A71 infection in prospective cohort studies of children in southern China, 2013-2018

Juan Yang, Qiaohong Liao, Kaiwei Luo, Fengfeng Liu, Yonghong Zhou, Gang Zou, Wei Huang, Shuanbao Yu, Xianglin Wei, Jiaxin Zhou, Bingbing Dai, Qi Qiu, Ralf Altmeyer, Hongan Hu, Juliette Paireau, Li Luo, Lidong Gao, Birgit Nikolay, Shixiong Hu, Weijia Xing, Peng Wu, H. Rogier Doorn, Peter W. Horby, Peter Simmonds, Gabriel M. Leung, Benjamin J. Cowling, Simon Cauchemez and Hongjie Yu ()
Additional contact information
Juan Yang: Ministry of Education
Qiaohong Liao: Ministry of Education
Kaiwei Luo: Hunan Provincial Center for Disease Control and Prevention (Workstation for Emerging Infectious Disease Control and Prevention, Chinese Academy of Medical Sciences)
Fengfeng Liu: Chinese Center for Disease Control and Prevention
Yonghong Zhou: Ministry of Education
Gang Zou: Chinese Academy of Sciences
Wei Huang: Hunan Provincial Center for Disease Control and Prevention (Workstation for Emerging Infectious Disease Control and Prevention, Chinese Academy of Medical Sciences)
Shuanbao Yu: Chinese Center for Disease Control and Prevention
Xianglin Wei: Ministry of Education
Jiaxin Zhou: Ministry of Education
Bingbing Dai: Anhua County Center for Disease Control and Prevention
Qi Qiu: Ministry of Education
Ralf Altmeyer: Chinese Academy of Sciences
Hongan Hu: Anhua County Center for Disease Control and Prevention
Juliette Paireau: Université Paris Cité, UMR2000, CNRS
Li Luo: Chinese Center for Disease Control and Prevention
Lidong Gao: Hunan Provincial Center for Disease Control and Prevention (Workstation for Emerging Infectious Disease Control and Prevention, Chinese Academy of Medical Sciences)
Birgit Nikolay: Université Paris Cité, UMR2000, CNRS
Shixiong Hu: Hunan Provincial Center for Disease Control and Prevention (Workstation for Emerging Infectious Disease Control and Prevention, Chinese Academy of Medical Sciences)
Weijia Xing: Chinese Center for Disease Control and Prevention
Peng Wu: The University of Hong Kong, Hong Kong Special Administrative Region
H. Rogier Doorn: Hospital for Tropical Diseases
Peter W. Horby: University of Oxford
Peter Simmonds: Hospital for Tropical Diseases
Gabriel M. Leung: The University of Hong Kong, Hong Kong Special Administrative Region
Benjamin J. Cowling: The University of Hong Kong, Hong Kong Special Administrative Region
Simon Cauchemez: Université Paris Cité, UMR2000, CNRS
Hongjie Yu: Ministry of Education

Nature Communications, 2022, vol. 13, issue 1, 1-10

Abstract: Abstract Enterovirus A71 (EV-A71)–related hand, foot, and mouth disease (HFMD) imposes a substantial clinical burden in the Asia Pacific region. To inform policy on the introduction of the EV-A71 vaccine into the National Immunization Programme, we investigated the seroepidemiological characteristics of EV-A71 in two prospective cohorts of children in southern China conducted between 2013 and 2018. Our results show that maternal antibody titres declined rapidly in neonates, with over half becoming susceptible to EV-A71 at 1 month of age. Between 6 months and 2 years of age, over 80% of study participants were susceptible, while one third remained susceptible at 5 years old. The highest incidence of EV-A71 infections was observed in children aged 5-6 months. Our findings support EV-A71 vaccination before 6 months for birth cohorts in southern China, potentially with a one-time catch-up vaccination for children 6 months-5 years old. More regionally representative longitudinal seroepidemiological studies are needed to further validate these findings.

Date: 2022
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DOI: 10.1038/s41467-022-34992-1

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