Arginine-modified black phosphorus quantum dots with dual excited states for enhanced electrochemiluminescence in bioanalysis

Siqi Yu, Yu Du, Xianghong Niu, Guangming Li, Da Zhu, Qian Yu, Guizheng Zou and Huangxian Ju ()
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Siqi Yu: Nanjing University
Yu Du: Nanjing University
Xianghong Niu: Nanjing University of Posts and Telecommunications
Guangming Li: Nanjing University
Da Zhu: Nanjing University
Qian Yu: Nanjing University
Guizheng Zou: Shandong University
Huangxian Ju: Nanjing University

Nature Communications, 2022, vol. 13, issue 1, 1-9

Abstract: Abstract The electrochemiluminescence (ECL) is generally emitted via radiative transition of singlet or triplet excited state (S1 or T1). Herein, an ECL mechanism with the transitions of both S1 and T1 of black phosphorus quantum dots (BPQDs) is found, and an arginine (Arg) modification strategy is proposed to passivate the surface oxidation defects of BPQDs, which could modulate the excited states for enhancing the ECL efficiency of BPQDs. The Arg modification leads to greater spatial overlap of highest and lowest occupied molecular orbitals, and spectral shift of radiative transitions, and improves the stability of anion radical of BPQDs. To verify the application of the proposed mechanism, it is used to construct a sensitive method for conveniently evaluating the inhibiting efficiency of cyclo-arginine-glycine-aspartic acid-d-tyrosine-lysine to cell surface integrin by using Arg containing peptide modified BPQDs as signal tag. The dual excited states mediated ECL emitters provide a paradigm for adjustable ECL generation and extend the application of ECL analysis.

Date: 2022
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DOI: 10.1038/s41467-022-35015-9

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