Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing

Yun Meng, Lijie Chen, Yang Chen, Jieyun Shi, Zheng Zhang, Yiwen Wang, Fan Wu, Xingwu Jiang, Wei Yang, Li Zhang, Chaochao Wang, Xianfu Meng, Yelin Wu () and Wenbo Bu ()
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Yun Meng: Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
Lijie Chen: Fudan University
Yang Chen: Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
Jieyun Shi: Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
Zheng Zhang: East China Normal University
Yiwen Wang: East China Normal University
Fan Wu: Fudan University
Xingwu Jiang: Fudan University
Wei Yang: Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
Li Zhang: Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
Chaochao Wang: Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
Xianfu Meng: Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
Yelin Wu: Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
Wenbo Bu: Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract Bacteria and excessive inflammation are two main factors causing non-healing wounds. However, current studies have mainly focused on the inhibition of bacteria survival for wound healing while ignoring the excessive inflammation induced by dead bacteria-released lipopolysaccharide (LPS) or peptidoglycan (PGN). Herein, a boron-trapping strategy has been proposed to prevent both infection and excessive inflammation by synthesizing a class of reactive metal boride nanoparticles (MB NPs). Our results show that the MB NPs are gradually hydrolyzed to generate boron dihydroxy groups and metal cations while generating a local alkaline microenvironment. This microenvironment greatly enhances boron dihydroxy groups to trap LPS or PGN through an esterification reaction, which not only enhances metal cation-induced bacterial death but also inhibits dead bacteria-induced excessive inflammation both in vitro and in vivo, finally accelerating wound healing. Taken together, this boron-trapping strategy provides an approach to the treatment of bacterial infection and the accompanying inflammation.

Date: 2022
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DOI: 10.1038/s41467-022-35050-6

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