Hippocampus as a sorter and reverberatory integrator of sensory inputs

Masanori Nomoto, Emi Murayama, Shuntaro Ohno, Reiko Okubo-Suzuki, Shin-ichi Muramatsu and Kaoru Inokuchi ()
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Masanori Nomoto: University of Toyama
Emi Murayama: University of Toyama
Shuntaro Ohno: University of Toyama
Reiko Okubo-Suzuki: University of Toyama
Shin-ichi Muramatsu: Jichi Medical University
Kaoru Inokuchi: University of Toyama

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract The hippocampus must be capable of sorting and integrating multiple sensory inputs separately but simultaneously. However, it remains to be elucidated how the hippocampus executes these processes simultaneously during learning. Here we found that synchrony between conditioned stimulus (CS)-, unconditioned stimulus (US)- and future retrieval-responsible cells occurs in the CA1 during the reverberatory phase that emerges after sensory inputs have ceased, but not during CS and US inputs. Mutant mice lacking N-methyl-D-aspartate receptors (NRs) in CA3 showed a cued-fear memory impairment and a decrease in synchronized reverberatory activities between CS- and US-responsive CA1 cells. Optogenetic CA3 silencing at the reverberatory phase during learning impaired cued-fear memory. Thus, the hippocampus uses reverberatory activity to link CS and US inputs, and avoid crosstalk during sensory inputs.

Date: 2022
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DOI: 10.1038/s41467-022-35119-2

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