Prior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination

Evi Schuppen, Janeri Fröberg, Prashanna Balaji Venkatasubramanian, Pauline Versteegen, Hans Graaf, Jana Holubová, Joshua Gillard, Pieter G. M. Gageldonk, Irma Joosten, Ronald Groot, Peter Šebo, Guy A. M. Berbers, Robert C. Read, Martijn A. Huynen, Marien I. Jonge and Dimitri A. Diavatopoulos ()
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Evi Schuppen: Radboud Institute for Molecular Life Sciences, Radboudumc
Janeri Fröberg: Radboud Institute for Molecular Life Sciences, Radboudumc
Prashanna Balaji Venkatasubramanian: Radboud Institute for Molecular Life Sciences, Radboudumc
Pauline Versteegen: Centre for Infectious Disease Control
Hans Graaf: University of Southampton, Academic Unit of Clinical Experimental Sciences, National Institute of Health Research (NIHR) Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton
Jana Holubová: Institute of Microbiology of the Czech Academy of Sciences
Joshua Gillard: Radboud Institute for Molecular Life Sciences, Radboudumc
Pieter G. M. Gageldonk: Centre for Infectious Disease Control
Irma Joosten: Radboud Institute for Molecular Life Sciences, Radboudumc
Ronald Groot: Radboud Institute for Molecular Life Sciences, Radboudumc
Peter Šebo: Institute of Microbiology of the Czech Academy of Sciences
Guy A. M. Berbers: Centre for Infectious Disease Control
Robert C. Read: University of Southampton, Academic Unit of Clinical Experimental Sciences, National Institute of Health Research (NIHR) Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton
Martijn A. Huynen: Radboud Institute for Molecular Life Sciences, Radboudumc
Marien I. Jonge: Radboud Institute for Molecular Life Sciences, Radboudumc
Dimitri A. Diavatopoulos: Radboud Institute for Molecular Life Sciences, Radboudumc

Nature Communications, 2022, vol. 13, issue 1, 1-11

Abstract: Abstract Bordetella pertussis (Bp), the causative agent of pertussis, continues to circulate despite widespread vaccination programs. An important question is whether and how (sub)clinical infections shape immune memory to Bp, particularly in populations primed with acellular pertussis vaccines (aP). Here, we examine the prevalence of mucosal antibodies against non-vaccine antigens in aP-primed children and adolescents of the BERT study (NCT03697798), using antibody binding to a Bp mutant strain lacking aP antigens (Bp_mut). Our study identifies increased levels of mucosal IgG and IgA binding to Bp_mut in older aP-primed individuals, suggesting different Bp exposure between aP-primed birth cohorts, in line with pertussis disease incidence data. To examine whether Bp exposure influences vaccination responses, we measured mucosal antibody responses to aP booster vaccination as a secondary study outcome. Although booster vaccination induces significant increases in mucosal antibodies to Bp in both cohorts, the older age group that had higher baseline antibodies to Bp_ mut shows increased persistence of antibodies after vaccination.

Date: 2022
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DOI: 10.1038/s41467-022-35165-w

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