SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice

Tatsuya Yoshizawa (), Yoshifumi Sato, Shihab U. Sobuz, Tomoya Mizumoto, Tomonori Tsuyama, Md. Fazlul Karim, Keishi Miyata, Masayoshi Tasaki, Masaya Yamazaki, Yuichi Kariba, Norie Araki, Eiichi Araki, Shingo Kajimura, Yuichi Oike, Thomas Braun, Eva Bober, Johan Auwerx and Kazuya Yamagata ()
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Tatsuya Yoshizawa: Kumamoto University
Yoshifumi Sato: Kumamoto University
Shihab U. Sobuz: Kumamoto University
Tomoya Mizumoto: Kumamoto University
Tomonori Tsuyama: Kumamoto University
Md. Fazlul Karim: Kumamoto University
Keishi Miyata: Kumamoto University
Masayoshi Tasaki: Kumamoto University
Masaya Yamazaki: Kumamoto University
Yuichi Kariba: Kumamoto University
Norie Araki: Kumamoto University
Eiichi Araki: Kumamoto University
Shingo Kajimura: Beth Israel Deaconess Medical Center, Harvard Medical School, and Howard Hughes Medical Institute
Yuichi Oike: Kumamoto University
Thomas Braun: Max-Planck-Institute for Heart and Lung Research
Eva Bober: Max-Planck-Institute for Heart and Lung Research
Johan Auwerx: École Polytechnique Fédérale de Lausanne
Kazuya Yamagata: Kumamoto University

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract Brown adipose tissue plays a central role in the regulation of the energy balance by expending energy to produce heat. NAD+-dependent deacylase sirtuins have widely been recognized as positive regulators of brown adipose tissue thermogenesis. However, here we reveal that SIRT7, one of seven mammalian sirtuins, suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions. Whole-body and brown adipose tissue-specific Sirt7 knockout mice have higher body temperature and energy expenditure. SIRT7 deficiency increases the protein level of UCP1, a key regulator of brown adipose tissue thermogenesis. Mechanistically, we found that SIRT7 deacetylates insulin-like growth factor 2 mRNA-binding protein 2, an RNA-binding protein that inhibits the translation of Ucp1 mRNA, thereby enhancing its inhibitory action on Ucp1. Furthermore, SIRT7 attenuates the expression of batokine genes, such as fibroblast growth factor 21. In conclusion, we propose that SIRT7 serves as an energy-saving factor by suppressing brown adipose tissue functions.

Date: 2022
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DOI: 10.1038/s41467-022-35219-z

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