Perfluorodecalin-based oxygenated emulsion as a topical treatment for chemical burn to the eye

Sanming Li, Kunpeng Pang, Shuyan Zhu, Kathryn Pate and Jia Yin ()
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Sanming Li: Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Department of Ophthalmology
Kunpeng Pang: Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Department of Ophthalmology
Shuyan Zhu: Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Department of Ophthalmology
Kathryn Pate: Coruna Medical, LLC
Jia Yin: Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Department of Ophthalmology

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract Chemical injuries to the eye are emergencies with limited acute treatment options other than prompt irrigation and can cause permanent vision loss. We developed a perfluorodecalin-based supersaturated oxygen emulsion (SSOE) to topically deliver high concentration of oxygen to the eye. SSOE is manufactured in hyperbaric conditions and stored in a ready-to-use canister. Upon dispensation, SSOE rapidly raises partial oxygen pressure 3 times over atmospheric level. SSOE is biocompatible with human corneal cells and safe on mouse eyes in vivo. A single topical application of SSOE to the eye after alkali injury significantly promotes corneal epithelial wound healing, decreases anterior chamber exudation, and reduces optical opacity and cataract formation in mice. SSOE treatment reduces intraocular hypoxia, cell death, leukocyte infiltration, production of inflammatory mediators, and hypoxia-inducible factor 1-alpha signaling, thus hastening recovery of normal tissue integrity during the wound healing process. Here, we show that SSOE is an effective topical therapeutic in the acute treatment of ocular chemical injuries.

Date: 2022
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DOI: 10.1038/s41467-022-35241-1

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