GABAergic neurons in the rostromedial tegmental nucleus are essential for rapid eye movement sleep suppression

Ya-Nan Zhao, Jian-Bo Jiang, Shi-Yuan Tao, Yang Zhang, Ze-Ka Chen, Wei-Min Qu (), Zhi-Li Huang () and Su-Rong Yang ()
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Ya-Nan Zhao: Fudan University
Jian-Bo Jiang: Fudan University
Shi-Yuan Tao: Fudan University
Yang Zhang: Fudan University
Ze-Ka Chen: Fudan University
Wei-Min Qu: Fudan University
Zhi-Li Huang: Fudan University
Su-Rong Yang: Fudan University

Nature Communications, 2022, vol. 13, issue 1, 1-18

Abstract: Abstract Rapid eye movement (REM) sleep disturbances are prevalent in various psychiatric disorders. However, the neural circuits that regulate REM sleep remain poorly understood. Here, we found that in male mice, optogenetic activation of rostromedial tegmental nucleus (RMTg) GABAergic neurons immediately converted REM sleep to arousal and then initiated non-REM (NREM) sleep. Conversely, laser-mediated inactivation completely converted NREM to REM sleep and prolonged REM sleep duration. The activity of RMTg GABAergic neurons increased to a high discharge level at the termination of REM sleep. RMTg GABAergic neurons directly converted REM sleep to wakefulness and NREM sleep via inhibitory projections to the laterodorsal tegmentum (LDT) and lateral hypothalamus (LH), respectively. Furthermore, LDT glutamatergic neurons were responsible for the REM sleep-wake transitions following photostimulation of the RMTgGABA-LDT circuit. Thus, RMTg GABAergic neurons are essential for suppressing the induction and maintenance of REM sleep.

Date: 2022
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DOI: 10.1038/s41467-022-35299-x

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