An umbrella review of the evidence linking oral health and systemic noncommunicable diseases

João Botelho (), Paulo Mascarenhas, João Viana, Luís Proença, Marco Orlandi, Yago Leira, Leandro Chambrone, José João Mendes and Vanessa Machado
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João Botelho: Egas Moniz—Cooperativa de Ensino Superior, CRL
Paulo Mascarenhas: Egas Moniz—Cooperativa de Ensino Superior, CRL
João Viana: Egas Moniz—Cooperativa de Ensino Superior, CRL
Luís Proença: Egas Moniz—Cooperativa de Ensino Superior, CRL
Marco Orlandi: University College London
Yago Leira: University College London
Leandro Chambrone: Egas Moniz—Cooperativa de Ensino Superior, CRL
José João Mendes: Egas Moniz—Cooperativa de Ensino Superior, CRL
Vanessa Machado: Egas Moniz—Cooperativa de Ensino Superior, CRL

Nature Communications, 2022, vol. 13, issue 1, 1-11

Abstract: Abstract Oral diseases are highly prevalent worldwide. Recent studies have been supporting a potential bidirectional association of oral diseases with systemic noncommunicable diseases (NCDs). Available evidence supports that people with NCDs have a greater prevalence of oral diseases particularly those with limited ability of oral self-care. Regarding the reverse relationship, the lines of evidence pointing out NCDs as putative risk factors for oral diseases have increased significantly but not with a consistent agreement. This umbrella review of meta-analyses appraises the strength and validity of the evidence for the association between oral health and systemic health (registered at PROSPERO, ID: CRD42022300740). An extensive search included systematic reviews that have provided meta-analytic estimates on the association of oral diseases with NCDs. The overall strength of evidence was found to be unfavorable and with methodological inconsistencies. Twenty-eight NCDs were strongly associated with oral diseases. Among those NCDs are five types of cancer, diabetes mellitus, cardiovascular diseases, depression, neurodegenerative conditions, rheumatic diseases, inflammatory bowel disease, gastric helicobacter pylori, obesity, and asthma. According to fail-safe number statistics, the evidence levels are unlikely to change in the future, indicating a fairly robust consistency.

Date: 2022
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DOI: 10.1038/s41467-022-35337-8

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