Temperature-adaptive hydrogel optical waveguide with soft tissue-affinity for thermal regulated interventional photomedicine

Guoyin Chen, Kai Hou (), Nuo Yu, Peiling Wei, Tao Chen, Caihong Zhang, Shun Wang, Hongmei Liu, Ran Cao (), Liping Zhu, Benjamin S. Hsiao and Meifang Zhu ()
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Guoyin Chen: Donghua University
Kai Hou: Donghua University
Nuo Yu: Donghua University
Peiling Wei: Donghua University
Tao Chen: Donghua University
Caihong Zhang: Donghua University
Shun Wang: Donghua University
Hongmei Liu: Donghua University
Ran Cao: Donghua University
Liping Zhu: Donghua University
Benjamin S. Hsiao: Donghua University
Meifang Zhu: Donghua University

Nature Communications, 2022, vol. 13, issue 1, 1-9

Abstract: Abstract Photomedicine has gained great attention due to its nontoxicity, good selectivity and small trauma. However, owing to the limited penetration of light and difficult monitoring of the photo-media therapies, it is challenging to apply photomedical treatment in deep tissue as they may damage normal tissues. Herein, a thermal regulated interventional photomedicine based on a temperature-adaptive hydrogel fiber-based optical waveguide (THFOW) is proposed, capable of eliminating deeply seated tumor cells while lowering risks of overtemperature (causes the death of healthy cells around the tumor). The THFOW is fabricated by an integrated homogeneous-dynamic-crosslinking-spinning method, and shows a remarkable soft tissue-affinity (low cytotoxicity, swelling stability, and soft tissue-like Young’s modulus). Moreover, the THFOW shows an excellent light propagation property with different wavenumbers (especially −0.32 dB cm−1 with 915 nm laser light), and temperature-gated light propagation effect. The THFOW and relevant therapeutic strategy offer a promising application for intelligent photomedicine in deep issue.

Date: 2022
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DOI: 10.1038/s41467-022-35440-w

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