Lossless enrichment of trace analytes in levitating droplets for multiphase and multiplex detection

Xueyan Chen, Qianqian Ding, Chao Bi, Jian Ruan () and Shikuan Yang ()
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Xueyan Chen: Zhejiang University
Qianqian Ding: Zhejiang University
Chao Bi: Zhejiang University School of Medicine
Jian Ruan: Zhejiang University School of Medicine
Shikuan Yang: Zhejiang University

Nature Communications, 2022, vol. 13, issue 1, 1-9

Abstract: Abstract Concentrating a trace amount of molecules from liquids, solid objects, or the gas phase and delivering them to a localized area are crucial for almost any trace analyte detection device. Analytes within a liquid droplet resting on micro/nanostructured surfaces with liquid-repellent coatings can be concentrated during solvent evaporation. However, these coatings suffer from complex manufacturing procedures, poor versatility, and limited analyte enrichment efficiency. Here, we report on the use of an acoustic levitation platform to losslessly concentrate the analyte molecules dissolved in any volatile liquid, attached to solid objects, or spread in air. Gold nanoparticles can be simultaneously concentrated with the analytes in different phases, realizing sensitive, surface-enhanced Raman scattering detection even at attomolar (10−18 mol/L) concentration levels. The acoustic levitation platform-enabled, lossless analyte enrichment can significantly increase the analytical performance of many conventional microsensing techniques.

Date: 2022
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DOI: 10.1038/s41467-022-35495-9

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