Atomically dispersed golds on degradable zero-valent copper nanocubes augment oxygen driven Fenton-like reaction for effective orthotopic tumor therapy

Liu-Chun Wang, Li-Chan Chang, Wen-Qi Chen, Yi-Hsin Chien, Po-Ya Chang, Chih-Wen Pao, Yin-Fen Liu, Hwo-Shuenn Sheu (), Wen-Pin Su (), Chen-Hao Yeh () and Chen-Sheng Yeh ()
Additional contact information
Liu-Chun Wang: National Cheng Kung University
Li-Chan Chang: National Cheng Kung University
Wen-Qi Chen: National Cheng Kung University
Yi-Hsin Chien: Feng Chia University
Po-Ya Chang: National Synchrotron Radiation Research Center
Chih-Wen Pao: National Synchrotron Radiation Research Center
Yin-Fen Liu: National Cheng Kung University
Hwo-Shuenn Sheu: National Synchrotron Radiation Research Center
Wen-Pin Su: National Cheng Kung University
Chen-Hao Yeh: Feng Chia University
Chen-Sheng Yeh: National Cheng Kung University

Nature Communications, 2022, vol. 13, issue 1, 1-17

Abstract: Abstract Herein, we employ a galvanic replacement approach to create atomically dispersed Au on degradable zero-valent Cu nanocubes for tumor treatments on female mice. Controlling the addition of precursor HAuCl4 allows for the fabrication of different atomic ratios of AuxCuy. X-ray absorption near edge spectra indicates that Au and Cu are the predominant oxidation states of zero valence. This suggests that the charges of Au and Cu remain unchanged after galvanic replacement. Specifically, Au0.02Cu0.98 composition reveals the enhanced •OH generation following O2 → H2O2 → •OH. The degradable Au0.02Cu0.98 released Cu+ and Cu2+ resulting in oxygen reduction and Fenton-like reactions. Simulation studies indicate that Au single atoms boot zero-valent copper to reveal the catalytic capability of Au0.02Cu0.98 for O2 → H2O2 → •OH as well. Instead of using endogenous H2O2, H2O2 can be sourced from the O2 in the air through the use of nanocubes. Notably, the Au0.02Cu0.98 structure is degradable and renal-clearable.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-022-35515-8 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35515-8

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-35515-8

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().