A secreted effector with a dual role as a toxin and as a transcriptional factor

Dandan Wang, Lingfang Zhu, Xiangkai Zhen, Daoyan Yang, Changfu Li, Yating Chen, Huannan Wang, Yichen Qu, Xiaozhen Liu, Yanling Yin, Huawei Gu, Lei Xu, Chuanxing Wan, Yao Wang, Songying Ouyang () and Xihui Shen ()
Additional contact information
Dandan Wang: Northwest A&F University
Lingfang Zhu: Northwest A&F University
Xiangkai Zhen: Fujian Normal University
Daoyan Yang: Northwest A&F University
Changfu Li: Northwest A&F University
Yating Chen: Northwest A&F University
Huannan Wang: Fujian Normal University
Yichen Qu: Northwest A&F University
Xiaozhen Liu: Northwest A&F University
Yanling Yin: Tarim University
Huawei Gu: Northwest A&F University
Lei Xu: Northwest A&F University
Chuanxing Wan: Tarim University
Yao Wang: Northwest A&F University
Songying Ouyang: Fujian Normal University
Xihui Shen: Northwest A&F University

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Bacteria have evolved multiple secretion systems for delivering effector proteins into the cytosol of neighboring cells, but the roles of many of these effectors remain unknown. Here, we show that Yersinia pseudotuberculosis secretes an effector, CccR, that can act both as a toxin and as a transcriptional factor. The effector is secreted by a type VI secretion system (T6SS) and can enter nearby cells of the same species and other species (such as Escherichia coli) via cell-cell contact and in a contact-independent manner. CccR contains an N-terminal FIC domain and a C-terminal DNA-binding domain. In Y. pseudotuberculosis cells, CccR inhibits its own expression by binding through its DNA-binding domain to the cccR promoter, and affects the expression of other genes through unclear mechanisms. In E. coli cells, the FIC domain of CccR AMPylates the cell division protein FtsZ, inducing cell filamentation and growth arrest. Thus, our results indicate that CccR has a dual role, modulating gene expression in neighboring cells of the same species, and inhibiting the growth of competitors.

Date: 2022
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DOI: 10.1038/s41467-022-35522-9

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