Ni-catalyzed benzylic β-C(sp3)–H bond activation of formamides

Rong-Hua Wang, Wei-Wei Xu, Hongli Wu, Yue Li, Jiang-Fei Li, Tao Zhang, Genping Huang () and Mengchun Ye ()
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Rong-Hua Wang: Nankai University
Wei-Wei Xu: Nankai University
Hongli Wu: Tianjin University
Yue Li: Nankai University
Jiang-Fei Li: Nankai University
Tao Zhang: Nankai University
Genping Huang: Tianjin University
Mengchun Ye: Nankai University

Nature Communications, 2022, vol. 13, issue 1, 1-9

Abstract: Abstract The development of transition metal-catalyzed β-C–H bond activation via highly-strained 4-membered metallacycles has been a formidable task. So far, only scarce examples have been reported to undergo β-C–H bond activation via 4-membered metallacycles, and all of them rely on precious metals. In contrast, earth-abundant and inexpensive 3d transition metal-catalyzed β-C–H bond activation via 4-membered metallacycles still remains an elusive challenge. Herein, we report a phosphine oxide-ligated Ni−Al bimetallic catalyst to activate secondary benzylic C(sp3)–H bonds of formamides via 4-membered nickelacycles, providing a series of α,β-unsaturated γ-lactams in up to 97% yield.

Date: 2022
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DOI: 10.1038/s41467-022-35541-6

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