A pH-responsive T1-T2 dual-modal MRI contrast agent for cancer imaging

Hongwei Lu, An Chen, Xindan Zhang, Zixiang Wei, Rong Cao, Yi Zhu, Jingxiong Lu, Zhongling Wang () and Leilei Tian ()
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Hongwei Lu: Southern University of Science and Technology
An Chen: Shanghai Jiaotong University
Xindan Zhang: Southern University of Science and Technology
Zixiang Wei: Southern University of Science and Technology
Rong Cao: Shanghai Jiaotong University
Yi Zhu: Shanghai Jiaotong University
Jingxiong Lu: Southern University of Science and Technology
Zhongling Wang: Shanghai Jiaotong University
Leilei Tian: Southern University of Science and Technology

Nature Communications, 2022, vol. 13, issue 1, 1-12

Abstract: Abstract Magnetic resonance imaging (MRI) is a non-invasive imaging technology to diagnose health conditions, showing the weakness of low sensitivity. Herein, we synthesize a contrast agent, SPIO@SiO2@MnO2, which shows decreased T1 and T2 contrast intensity in normal physiological conditions. In the acid environment of tumor or inflamed tissue, the manganese dioxide (MnO2) layer decomposes into magnetically active Mn2+ (T1-weighted), and the T1 and T2 signals are sequentially recovered. In addition, both constrast quenching-activation degrees of T1 and T2 images can be accurately regulated by the silicon dioxide (SiO2) intermediate layer between superparamagnetic iron oxide (SPIO) and MnO2. Through the “dual-contrast enhanced subtraction” imaging processing technique, the contrast sensitivity of this MRI contrast agent is enhanced to a 12.3-time difference between diseased and normal tissue. Consequently, SPIO@SiO2@MnO2 is successfully applied to trace the tiny liver metastases of approximately 0.5 mm and monitor tissue inflammation.

Date: 2022
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DOI: 10.1038/s41467-022-35655-x

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