Rapidly shifting immunologic landscape and severity of SARS-CoV-2 in the Omicron era in South Africa

Kaiyuan Sun (), Stefano Tempia, Jackie Kleynhans, Anne Gottberg, Meredith L. McMorrow, Nicole Wolter, Jinal N. Bhiman, Jocelyn Moyes, Maimuna Carrim, Neil A. Martinson, Kathleen Kahn, Limakatso Lebina, Jacques D. Toit, Thulisa Mkhencele, Cécile Viboud and Cheryl Cohen ()
Additional contact information
Kaiyuan Sun: Fogarty International Center, National Institutes of Health
Stefano Tempia: National Institute for Communicable Diseases of the National Health Laboratory Service
Jackie Kleynhans: National Institute for Communicable Diseases of the National Health Laboratory Service
Anne Gottberg: National Institute for Communicable Diseases of the National Health Laboratory Service
Meredith L. McMorrow: Centers for Disease Control and Prevention
Nicole Wolter: National Institute for Communicable Diseases of the National Health Laboratory Service
Jinal N. Bhiman: National Institute for Communicable Diseases of the National Health Laboratory Service
Jocelyn Moyes: National Institute for Communicable Diseases of the National Health Laboratory Service
Maimuna Carrim: National Institute for Communicable Diseases of the National Health Laboratory Service
Neil A. Martinson: University of the Witwatersrand
Kathleen Kahn: University of the Witwatersrand
Limakatso Lebina: University of the Witwatersrand
Jacques D. Toit: University of the Witwatersrand
Thulisa Mkhencele: National Institute for Communicable Diseases of the National Health Laboratory Service
Cécile Viboud: Fogarty International Center, National Institutes of Health
Cheryl Cohen: National Institute for Communicable Diseases of the National Health Laboratory Service

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract South Africa was among the first countries to detect the SARS-CoV-2 Omicron variant. However, the size of its Omicron BA.1 and BA.2 subvariants (BA.1/2) wave remains poorly understood. We analyzed sequential serum samples collected through a prospective cohort study before, during, and after the Omicron BA.1/2 wave to infer infection rates and monitor changes in the immune histories of participants over time. We found that the Omicron BA.1/2 wave infected more than half of the cohort population, with reinfections and vaccine breakthroughs accounting for > 60% of all infections in both rural and urban sites. After the Omicron BA.1/2 wave, we found few (

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/s41467-022-35652-0 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-022-35652-0

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-35652-0

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().