Effects of tuberculosis and/or HIV-1 infection on COVID-19 presentation and immune response in Africa

Elsa du Bruyn, Cari Stek, Remi Daroowala, Qonita Said-Hartley, Marvin Hsiao, Georgia Schafer, Rene T. Goliath, Fatima Abrahams, Amanda Jackson, Sean Wasserman, Brian W. Allwood, Angharad G. Davis, Rachel P.-J. Lai, Anna K. Coussens, Katalin A. Wilkinson, Jantina de Vries, Nicki Tiffin, Maddalena Cerrone, Ntobeko A. B. Ntusi, Catherine Riou () and Robert J. Wilkinson ()
Additional contact information
Elsa du Bruyn: University of Cape Town
Cari Stek: University of Cape Town
Remi Daroowala: University of Cape Town
Qonita Said-Hartley: University of Cape Town
Marvin Hsiao: University of Cape Town
Georgia Schafer: University of Cape Town
Rene T. Goliath: University of Cape Town
Fatima Abrahams: University of Cape Town
Amanda Jackson: University of Cape Town
Sean Wasserman: University of Cape Town
Brian W. Allwood: Stellenbosch University and Tygerberg Hospital
Angharad G. Davis: University of Cape Town
Rachel P.-J. Lai: University of Cape Town
Anna K. Coussens: University of Cape Town
Katalin A. Wilkinson: University of Cape Town
Jantina de Vries: University of Cape Town
Nicki Tiffin: University of Cape Town
Maddalena Cerrone: University of Cape Town
Ntobeko A. B. Ntusi: University of Cape Town
Catherine Riou: University of Cape Town
Robert J. Wilkinson: University of Cape Town

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract Few studies from Africa have described the clinical impact of co-infections on SARS-CoV-2 infection. Here, we investigate the presentation and outcome of SARS-CoV-2 infection in an African setting of high HIV-1 and tuberculosis prevalence by an observational case cohort of SARS-CoV-2 patients. A comparator group of non SARS-CoV-2 participants is included. The study includes 104 adults with SARS-CoV-2 infection of whom 29.8% are HIV-1 co-infected. Two or more co-morbidities are present in 57.7% of participants, including HIV-1 (30%) and active tuberculosis (14%). Amongst patients dually infected by tuberculosis and SARS-CoV-2, clinical features can be typical of either SARS-CoV-2 or tuberculosis: lymphopenia is exacerbated, and some markers of inflammation (D-dimer and ferritin) are further elevated (p

Date: 2023
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DOI: 10.1038/s41467-022-35689-1

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