In vivo clonal tracking reveals evidence of haemangioblast and haematomesoblast contribution to yolk sac haematopoiesis

C. Biben, T. S. Weber, K. S. Potts, J. Choi, D. C. Miles, A. Carmagnac, T. Sargeant, C. A. Graaf, K. A. Fennell, A. Farley, O. J. Stonehouse, M. A. Dawson, D. J. Hilton, S. H. Naik () and S. Taoudi ()
Additional contact information
C. Biben: The Walter and Eliza Hall Institute of Medical Research
T. S. Weber: The Walter and Eliza Hall Institute of Medical Research
K. S. Potts: The Walter and Eliza Hall Institute of Medical Research
J. Choi: The Walter and Eliza Hall Institute of Medical Research
D. C. Miles: The Walter and Eliza Hall Institute of Medical Research
A. Carmagnac: The Walter and Eliza Hall Institute of Medical Research
T. Sargeant: The Walter and Eliza Hall Institute of Medical Research
C. A. Graaf: The Walter and Eliza Hall Institute of Medical Research
K. A. Fennell: Peter MacCallum Cancer Centre
A. Farley: The Walter and Eliza Hall Institute of Medical Research
O. J. Stonehouse: The Walter and Eliza Hall Institute of Medical Research
M. A. Dawson: Peter MacCallum Cancer Centre
D. J. Hilton: The Walter and Eliza Hall Institute of Medical Research
S. H. Naik: The Walter and Eliza Hall Institute of Medical Research
S. Taoudi: The Walter and Eliza Hall Institute of Medical Research

Nature Communications, 2023, vol. 14, issue 1, 1-14

Abstract: Abstract During embryogenesis, haematopoietic and endothelial lineages emerge closely in time and space. It is thought that the first blood and endothelium derive from a common clonal ancestor, the haemangioblast. However, investigation of candidate haemangioblasts in vitro revealed the capacity for mesenchymal differentiation, a feature more compatible with an earlier mesodermal precursor. To date, no evidence for an in vivo haemangioblast has been discovered. Using single cell RNA-Sequencing and in vivo cellular barcoding, we have unravelled the ancestral relationships that give rise to the haematopoietic lineages of the yolk sac, the endothelium, and the mesenchyme. We show that the mesodermal derivatives of the yolk sac are produced by three distinct precursors with dual-lineage outcomes: the haemangioblast, the mesenchymoangioblast, and a previously undescribed cell type: the haematomesoblast. Between E5.5 and E7.5, this trio of precursors seeds haematopoietic, endothelial, and mesenchymal trajectories.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-022-35744-x Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-022-35744-x

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-35744-x

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().