Nucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice

Huan Sheng, Chao Lei, Yu Yuan, Yali Fu, Dongyang Cui, Li Yang, Da Shao, Zixuan Cao, Hao Yang, Xinli Guo, Chenshan Chu, Yaxian Wen, Zhangyin Cai, Ming Chen (), Bin Lai () and Ping Zheng ()
Additional contact information
Huan Sheng: Fudan University
Chao Lei: Fudan University
Yu Yuan: Fudan University
Yali Fu: Fudan University
Dongyang Cui: Fudan University
Li Yang: Fudan University
Da Shao: Fudan University
Zixuan Cao: Fudan University
Hao Yang: Fudan University
Xinli Guo: Fudan University
Chenshan Chu: Fudan University
Yaxian Wen: Fudan University
Zhangyin Cai: Fudan University
Ming Chen: Fudan University
Bin Lai: Fudan University
Ping Zheng: Fudan University

Nature Communications, 2023, vol. 14, issue 1, 1-16

Abstract: Abstract The lateral hypothalamus (LH) is physiologically critical in brain functions. The LH also plays an important role in drug addiction. However, neural circuits underlying LH involvement of drug addiction remain obscure. In the present study,our results showed that in male mice, during context-induced expression of morphine withdrawal memory, LH glutamatergic neurons played an important role; dopamine D1 receptor-expressing medium spiny neurons (D1-MSNs) projecting from the core of nucleus accumbens (NAcC) to the LH were an important upstream circuit to activate LH glutamatergic neurons; D1-MSNs projecting from the NAcC to the LH activated LH glutamatergic neurons through inhibiting LH local gamma-aminobutyric acid (GABA) neurons. These results suggest that disinhibited LH glutamatergic neurons by neural circuits from the NAcC importantly contribute to context-induced the expression of morphine withdrawal memory.

Date: 2023
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DOI: 10.1038/s41467-022-35758-5

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