Volumetric additive manufacturing of pristine silk-based (bio)inks

Maobin Xie, Liming Lian, Xuan Mu, Zeyu Luo, Carlos Ezio Garciamendez-Mijares, Zhenrui Zhang, Arturo López, Jennifer Manríquez, Xiao Kuang, Junqi Wu, Jugal Kishore Sahoo, Federico Zertuche González, Gang Li, Guosheng Tang, Sushila Maharjan, Jie Guo, David L. Kaplan and Yu Shrike Zhang ()
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Maobin Xie: Brigham and Women’s Hospital, Harvard Medical School
Liming Lian: Brigham and Women’s Hospital, Harvard Medical School
Xuan Mu: Brigham and Women’s Hospital, Harvard Medical School
Zeyu Luo: Brigham and Women’s Hospital, Harvard Medical School
Carlos Ezio Garciamendez-Mijares: Brigham and Women’s Hospital, Harvard Medical School
Zhenrui Zhang: Brigham and Women’s Hospital, Harvard Medical School
Arturo López: Brigham and Women’s Hospital, Harvard Medical School
Jennifer Manríquez: Brigham and Women’s Hospital, Harvard Medical School
Xiao Kuang: Brigham and Women’s Hospital, Harvard Medical School
Junqi Wu: Tufts University
Jugal Kishore Sahoo: Tufts University
Federico Zertuche González: Brigham and Women’s Hospital, Harvard Medical School
Gang Li: Tufts University
Guosheng Tang: Brigham and Women’s Hospital, Harvard Medical School
Sushila Maharjan: Brigham and Women’s Hospital, Harvard Medical School
Jie Guo: Brigham and Women’s Hospital, Harvard Medical School
David L. Kaplan: Tufts University
Yu Shrike Zhang: Brigham and Women’s Hospital, Harvard Medical School

Nature Communications, 2023, vol. 14, issue 1, 1-17

Abstract: Abstract Volumetric additive manufacturing (VAM) enables fast photopolymerization of three-dimensional constructs by illuminating dynamically evolving light patterns in the entire build volume. However, the lack of bioinks suitable for VAM is a critical limitation. This study reports rapid volumetric (bio)printing of pristine, unmodified silk-based (silk sericin (SS) and silk fibroin (SF)) (bio)inks to form sophisticated shapes and architectures. Of interest, combined with post-fabrication processing, the (bio)printed SS constructs reveal properties including reversible as well as repeated shrinkage and expansion, or shape-memory; whereas the (bio)printed SF constructs exhibit tunable mechanical performances ranging from a few hundred Pa to hundreds of MPa. Both types of silk-based (bio)inks are cytocompatible. This work supplies expanded bioink libraries for VAM and provides a path forward for rapid volumetric manufacturing of silk constructs, towards broadened biomedical applications.

Date: 2023
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DOI: 10.1038/s41467-023-35807-7

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