Near-infrared-IIb emitting single-atom catalyst for imaging-guided therapy of blood-brain barrier breakdown after traumatic brain injury

Biao Huang, Tao Tang, Shi-Hui Chen, Hao Li, Zhi-Jun Sun (), Zhi-Lin Zhang (), Mingxi Zhang () and Ran Cui ()
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Biao Huang: Wuhan University
Tao Tang: Wuhan University of Technology
Shi-Hui Chen: Wuhan University
Hao Li: Wuhan University
Zhi-Jun Sun: Wuhan University
Zhi-Lin Zhang: Wuhan University
Mingxi Zhang: Wuhan University of Technology
Ran Cui: Wuhan University

Nature Communications, 2023, vol. 14, issue 1, 1-16

Abstract: Abstract The blood-brain barrier breakdown, as a prominent feature after traumatic brain injury, always triggers a cascade of biochemical events like inflammatory response and free radical-mediated oxidative damage, leading to neurological dysfunction. The dynamic monitoring the status of blood-brain barrier will provide potent guidance for adopting appropriate clinical intervention. Here, we engineer a near-infrared-IIb Ag2Te quantum dot-based Mn single-atom catalyst for imaging-guided therapy of blood-brain barrier breakdown of mice after traumatic brain injury. The dynamic change of blood-brain barrier, including the transient cerebral hypoperfusion and cerebrovascular damage, could be resolved with high spatiotemporal resolution (150 ms and ~ 9.6 µm). Notably, the isolated single Mn atoms on the surface of Ag2Te exhibited excellent catalytic activity for scavenging reactive oxygen species to alleviate neuroinflammation in brains. The timely injection of Mn single-atom catalyst guided by imaging significantly promoted the reconstruction of blood-brain barrier and recovery of neurological function after traumatic brain injury.

Date: 2023
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DOI: 10.1038/s41467-023-35868-8

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