Endosomal sorting results in a selective separation of the protein corona from nanoparticles

Shen Han, Richard Costa Marques, Johanna Simon, Anke Kaltbeitzel, Kaloian Koynov, Katharina Landfester, Volker Mailänder and Ingo Lieberwirth ()
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Shen Han: Max Planck Institute for Polymer Research
Richard Costa Marques: Max Planck Institute for Polymer Research
Johanna Simon: Max Planck Institute for Polymer Research
Anke Kaltbeitzel: Max Planck Institute for Polymer Research
Kaloian Koynov: Max Planck Institute for Polymer Research
Katharina Landfester: Max Planck Institute for Polymer Research
Volker Mailänder: Max Planck Institute for Polymer Research
Ingo Lieberwirth: Max Planck Institute for Polymer Research

Nature Communications, 2023, vol. 14, issue 1, 1-12

Abstract: Abstract The formation of the protein corona is a well-known effect when nanoparticles (NP) are exposed to biological environments. The protein corona is the most important factor, which determines the rate and route of endocytosis, and decisively impacts cellular processes and even the release of the active pharmaceutical ingredient from the nanoparticles. While many studies concentrate on the effect of the protein corona formation extracellularly or the uptake consequences, little is known about the fate of the protein corona inside of cells. Here, we reconstruct for the first time the separation of the protein corona from the NPs by the cell and their further fate. Ultimately, the NPs and protein corona are separated from each other and end up in morphologically different cellular compartments. The cell directs the NPs towards recycling endosomes, whereas the protein corona gathers in multivesicular bodies. From this, we conclude that the NPs are prepared for subsequent exocytosis, while the protein corona remains in the cell and is finally metabolized there.

Date: 2023
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DOI: 10.1038/s41467-023-35902-9

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