A natural biological adhesive from snail mucus for wound repair

Tuo Deng, Dongxiu Gao, Xuemei Song, Zhipeng Zhou, Lixiao Zhou, Maixian Tao, Zexiu Jiang, Lian Yang, Lan Luo, Ankun Zhou, Lin Hu, Hongbo Qin and Mingyi Wu ()
Additional contact information
Tuo Deng: Chinese Academy of Sciences
Dongxiu Gao: Chinese Academy of Sciences
Xuemei Song: Chinese Academy of Sciences
Zhipeng Zhou: Chinese Academy of Sciences
Lixiao Zhou: Chinese Academy of Sciences
Maixian Tao: Chinese Academy of Sciences
Zexiu Jiang: Chinese Academy of Sciences
Lian Yang: Chinese Academy of Sciences
Lan Luo: Chinese Academy of Sciences
Ankun Zhou: Chinese Academy of Sciences
Lin Hu: Yunnan Minzu University
Hongbo Qin: Chinese Academy of Sciences
Mingyi Wu: Chinese Academy of Sciences

Nature Communications, 2023, vol. 14, issue 1, 1-18

Abstract: Abstract The discovery of natural adhesion phenomena and mechanisms has advanced the development of a new generation of tissue adhesives in recent decades. In this study, we develop a natural biological adhesive from snail mucus gel, which consists a network of positively charged protein and polyanionic glycosaminoglycan. The malleable bulk adhesive matrix can adhere to wet tissue through multiple interactions. The biomaterial exhibits excellent haemostatic activity, biocompatibility and biodegradability, and it is effective in accelerating the healing of full-thickness skin wounds in both normal and diabetic male rats. Further mechanistic study shows it effectively promotes the polarization of macrophages towards the anti-inflammatory phenotype, alleviates inflammation in chronic wounds, and significantly improves epithelial regeneration and angiogenesis. Its abundant heparin-like glycosaminoglycan component is the main active ingredient. These findings provide theoretical and material insights into bio-inspired tissue adhesives and bioengineered scaffold designs.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/s41467-023-35907-4 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-35907-4

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-35907-4

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().