Long-term statins administration exacerbates diabetic nephropathy via ectopic fat deposition in diabetic mice

Tong-sheng Huang, Teng Wu, Yan-di Wu, Xing-hui Li, Jing Tan, Cong-hui Shen, Shi-jie Xiong, Zi-qi Feng, Sai-fei Gao, Hui Li and Wei-bin Cai ()
Additional contact information
Tong-sheng Huang: Sun Yat-sen University
Teng Wu: Sun Yat-sen University
Yan-di Wu: Sun Yat-sen University
Xing-hui Li: Sun Yat-sen University
Jing Tan: Sun Yat-sen University
Cong-hui Shen: Sun Yat-sen University
Shi-jie Xiong: Sun Yat-sen University
Zi-qi Feng: Sun Yat-sen University
Sai-fei Gao: Sun Yat-sen University
Hui Li: Sun Yat-sen University
Wei-bin Cai: Sun Yat-sen University

Nature Communications, 2023, vol. 14, issue 1, 1-19

Abstract: Abstract Statins play an important role in the treatment of diabetic nephropathy. Increasing attention has been given to the relationship between statins and insulin resistance, but many randomized controlled trials confirm that the therapeutic effects of statins on diabetic nephropathy are more beneficial than harmful. However, further confirmation of whether the beneficial effects of chronic statin administration on diabetic nephropathy outweigh the detrimental effects is urgently needed. Here, we find that long-term statin administration may increase insulin resistance, interfere with lipid metabolism, leads to inflammation and fibrosis, and ultimately fuel diabetic nephropathy progression in diabetic mice. Mechanistically, activation of insulin-regulated phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway leads to increased fatty acid synthesis. Furthermore, statins administration increases lipid uptake and inhibits fatty acid oxidation, leading to lipid deposition. Here we show that long-term statins administration exacerbates diabetic nephropathy via ectopic fat deposition in diabetic mice.

Date: 2023
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-023-35944-z Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-35944-z

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-35944-z

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().