Complementary peptides represent a credible alternative to agrochemicals by activating translation of targeted proteins

Mélanie Ormancey, Bruno Guillotin, Rémy Merret, Laurent Camborde, Carine Duboé, Bertrand Fabre, Cécile Pouzet, Francis Impens, Delphi Haver, Marie-Christine Carpentier, Hélène San Clemente, Marielle Aguilar, Dominique Lauressergues, Lars B. Scharff, Carole Pichereaux, Odile Burlet-Schiltz, Cécile Bousquet-Antonelli, Kris Gevaert, Patrice Thuleau, Serge Plaza and Jean-Philippe Combier ()
Additional contact information
Mélanie Ormancey: Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT
Bruno Guillotin: Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT
Rémy Merret: Laboratoire Génome et Développement des Plantes, CNRS/UPVD
Laurent Camborde: Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT
Carine Duboé: Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT
Bertrand Fabre: Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT
Cécile Pouzet: Fédération de Recherche Agrobiosciences, Interactions et Biodiversité, UT3/CNRS
Francis Impens: VIB Center for Medical Biotechnology
Delphi Haver: VIB Center for Medical Biotechnology
Marie-Christine Carpentier: Laboratoire Génome et Développement des Plantes, CNRS/UPVD
Hélène San Clemente: Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT
Marielle Aguilar: Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT
Dominique Lauressergues: Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT
Lars B. Scharff: University of Copenhagen, Department of Plant and Environmental Sciences
Carole Pichereaux: Fédération de Recherche Agrobiosciences, Interactions et Biodiversité, UT3/CNRS
Odile Burlet-Schiltz: Institut de Pharmacologie et de Biologie Structurale, CNRS/UT3
Cécile Bousquet-Antonelli: Laboratoire Génome et Développement des Plantes, CNRS/UPVD
Kris Gevaert: VIB Center for Medical Biotechnology
Patrice Thuleau: Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT
Serge Plaza: Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT
Jean-Philippe Combier: Laboratoire de Recherche en Sciences Végétales, CNRS/UT3/INPT

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract The current agriculture main challenge is to maintain food production while facing multiple threats such as increasing world population, temperature increase, lack of agrochemicals due to health issues and uprising of weeds resistant to herbicides. Developing novel, alternative, and safe methods is hence of paramount importance. Here, we show that complementary peptides (cPEPs) from any gene can be designed to target specifically plant coding genes. External application of synthetic peptides increases the abundance of the targeted protein, leading to related phenotypes. Moreover, we provide evidence that cPEPs can be powerful tools in agronomy to improve plant traits, such as growth, resistance to pathogen or heat stress, without the needs of genetic approaches. Finally, by combining their activity they can also be used to reduce weed growth.

Date: 2023
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DOI: 10.1038/s41467-023-35951-0

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