Ethylene-triggered subcellular trafficking of CTR1 enhances the response to ethylene gas

Hye Lin Park, Dong Hye Seo, Han Yong Lee, Arkadipta Bakshi, Chanung Park, Yuan-Chi Chien, Joseph J. Kieber, Brad M. Binder and Gyeong Mee Yoon ()
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Hye Lin Park: Purdue University
Dong Hye Seo: Purdue University
Han Yong Lee: Purdue University
Arkadipta Bakshi: University of Tennessee
Chanung Park: Purdue University
Yuan-Chi Chien: Purdue University
Joseph J. Kieber: University of North Carolina
Brad M. Binder: University of Tennessee
Gyeong Mee Yoon: Purdue University

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract The phytohormone ethylene controls plant growth and stress responses. Ethylene-exposed dark-grown Arabidopsis seedlings exhibit dramatic growth reduction, yet the seedlings rapidly return to the basal growth rate when ethylene gas is removed. However, the underlying mechanism governing this acclimation of dark-grown seedlings to ethylene remains enigmatic. Here, we report that ethylene triggers the translocation of the Raf-like protein kinase CONSTITUTIVE TRIPLE RESPONSE1 (CTR1), a negative regulator of ethylene signaling, from the endoplasmic reticulum to the nucleus. Nuclear-localized CTR1 stabilizes the ETHYLENE-INSENSITIVE3 (EIN3) transcription factor by interacting with and inhibiting EIN3-BINDING F-box (EBF) proteins, thus enhancing the ethylene response and delaying growth recovery. Furthermore, Arabidopsis plants with enhanced nuclear-localized CTR1 exhibited improved tolerance to drought and salinity stress. These findings uncover a mechanism of the ethylene signaling pathway that links the spatiotemporal dynamics of cellular signaling components to physiological responses.

Date: 2023
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DOI: 10.1038/s41467-023-35975-6

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