Timing and cell specificity of senescence drives postnatal lung development and injury

Hongwei Yao (), Joselynn Wallace, Abigail L. Peterson, Alejandro Scaffa, Salu Rizal, Katy Hegarty, Hajime Maeda, Jason L. Chang, Nathalie Oulhen, Jill A. Kreiling, Kelsey E. Huntington, Monique E. Paepe, Guilherme Barbosa and Phyllis A. Dennery ()
Additional contact information
Hongwei Yao: Brown University
Joselynn Wallace: Brown University
Abigail L. Peterson: Brown University
Alejandro Scaffa: Brown University
Salu Rizal: Brown University
Katy Hegarty: Brown University
Hajime Maeda: Brown University
Jason L. Chang: Brown University
Nathalie Oulhen: Brown University
Jill A. Kreiling: Brown University
Kelsey E. Huntington: Brown University
Monique E. Paepe: Women and Infants Hospital
Guilherme Barbosa: Brown University
Phyllis A. Dennery: Brown University

Nature Communications, 2023, vol. 14, issue 1, 1-15

Abstract: Abstract Senescence causes age-related diseases and stress-related injury. Paradoxically, it is also essential for organismal development. Whether senescence contributes to lung development or injury in early life remains unclear. Here, we show that lung senescence occurred at birth and decreased throughout the saccular stage in mice. Reducing senescent cells at this stage disrupted lung development. In mice (

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-35985-4

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DOI: 10.1038/s41467-023-35985-4

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