Diverse secondary metabolites are expressed in particle-associated and free-living microorganisms of the permanently anoxic Cariaco Basin

David Geller-McGrath, Paraskevi Mara, Gordon T. Taylor, Elizabeth Suter, Virginia Edgcomb () and Maria Pachiadaki ()
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David Geller-McGrath: Woods Hole Oceanographic Institution
Paraskevi Mara: Woods Hole Oceanographic Institution
Gordon T. Taylor: Stony Brook University
Elizabeth Suter: Stony Brook University
Virginia Edgcomb: Woods Hole Oceanographic Institution
Maria Pachiadaki: Woods Hole Oceanographic Institution

Nature Communications, 2023, vol. 14, issue 1, 1-12

Abstract: Abstract Secondary metabolites play essential roles in ecological interactions and nutrient acquisition, and are of interest for their potential uses in medicine and biotechnology. Genome mining for biosynthetic gene clusters (BGCs) can be used for the discovery of new compounds. Here, we use metagenomics and metatranscriptomics to analyze BGCs in free-living and particle-associated microbial communities through the stratified water column of the Cariaco Basin, Venezuela. We recovered 565 bacterial and archaeal metagenome-assembled genomes (MAGs) and identified 1154 diverse BGCs. We show that differences in water redox potential and microbial lifestyle (particle-associated vs. free-living) are associated with variations in the predicted composition and production of secondary metabolites. Our results indicate that microbes, including understudied clades such as Planctomycetota, potentially produce a wide range of secondary metabolites in these anoxic/euxinic waters.

Date: 2023
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DOI: 10.1038/s41467-023-36026-w

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