Cryo-EM reveals the molecular basis of laminin polymerization and LN-lamininopathies

Arkadiusz W. Kulczyk (), Karen K. McKee, Ximo Zhang, Iwona Bizukojc, Ying Q. Yu and Peter D. Yurchenco
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Arkadiusz W. Kulczyk: Rutgers University
Karen K. McKee: Rutgers University - Robert Wood Johnson Medical School
Ximo Zhang: Waters Corporation
Iwona Bizukojc: Waters Corporation
Ying Q. Yu: Waters Corporation
Peter D. Yurchenco: Rutgers University - Robert Wood Johnson Medical School

Nature Communications, 2023, vol. 14, issue 1, 1-7

Abstract: Abstract Laminin polymerization is the major step in basement membranes assembly. Its failures cause laminin N-terminal domain lamininopathies including Pierson syndrome. We have employed cryo-electron microscopy to determine a 3.7 Å structure of the trimeric laminin polymer node containing α1, β1 and γ1 subunits. The structure reveals the molecular basis of calcium-dependent formation of laminin lattice, and provides insights into polymerization defects manifesting in human disease.

Date: 2023
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DOI: 10.1038/s41467-023-36077-z

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