SARS-CoV-2 humoral and cellular immunity following different combinations of vaccination and breakthrough infection

Jernej Pušnik, Werner O. Monzon-Posadas, Jasmin Zorn, Kathrin Peters, Maximilian Baum, Hannah Proksch, Celina Beta Schlüter, Galit Alter, Tanja Menting and Hendrik Streeck ()
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Jernej Pušnik: University Hospital Bonn
Werner O. Monzon-Posadas: University Hospital Bonn
Jasmin Zorn: University Hospital Bonn
Kathrin Peters: University Hospital Bonn
Maximilian Baum: University Hospital Bonn
Hannah Proksch: University Hospital Bonn
Celina Beta Schlüter: University Hospital Bonn
Galit Alter: Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital
Tanja Menting: University Hospital Bonn
Hendrik Streeck: University Hospital Bonn

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract The elicited anti-SARS-CoV-2 immunity is becoming increasingly complex with individuals receiving a different number of vaccine doses paired with or without recovery from breakthrough infections with different variants. Here we analyze the immunity of individuals that initially received two doses of mRNA vaccine and either received a booster vaccination, recovered from a breakthrough infection, or both. Our data suggest that two vaccine doses and delta breakthrough infection or three vaccine doses and optionally omicron or delta infection provide better B cell immunity than the initial two doses of mRNA vaccine with or without alpha breakthrough infection. A particularly potent B cell response against the currently circulating omicron variant (B. 1.1.529) was observed for thrice vaccinated individuals with omicron breakthrough infection; a 46-fold increase in plasma neutralization compared to two vaccine doses (p

Date: 2023
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DOI: 10.1038/s41467-023-36250-4

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