Epigenetic mechanisms underlying subtype heterogeneity and tumor recurrence in prostate cancer

Goutam Chakraborty, Kasmira Gupta and Natasha Kyprianou ()
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Goutam Chakraborty: Departments of Urology
Kasmira Gupta: Departments of Urology
Natasha Kyprianou: Departments of Urology

Nature Communications, 2023, vol. 14, issue 1, 1-4

Abstract: Prostate cancer is a highly heterogeneous disease. Progression on androgen deprivation therapy (ADT) to castration-resistant (CRPC), or neuroendocrine prostate cancer (NEPC), is associated with poor patient survival. This comment highlights recent evidence on the epigenetic mechanisms underlying the emergence of lineage plasticity and neuroendocrine differentiation in treatment-resistant prostate tumors.

Date: 2023
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DOI: 10.1038/s41467-023-36253-1

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