Transcriptional reprogramming of skeletal muscle stem cells by the niche environment

Felicia Lazure, Rick Farouni, Korin Sahinyan, Darren M. Blackburn, Aldo Hernández-Corchado, Gabrielle Perron, Tianyuan Lu, Adrien Osakwe, Jiannis Ragoussis, Colin Crist, Theodore J. Perkins, Arezu Jahani-Asl, Hamed S. Najafabadi () and Vahab D. Soleimani ()
Additional contact information
Felicia Lazure: McGill University, 3640 rue University
Rick Farouni: McGill University, 3640 rue University
Korin Sahinyan: McGill University, 3640 rue University
Darren M. Blackburn: McGill University, 3640 rue University
Aldo Hernández-Corchado: McGill University, 3640 rue University
Gabrielle Perron: McGill University, 3640 rue University
Tianyuan Lu: Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Chemin de la Côte-Sainte-Catherine
Adrien Osakwe: McGill University
Jiannis Ragoussis: McGill University, 3640 rue University
Colin Crist: McGill University, 3640 rue University
Theodore J. Perkins: Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute
Arezu Jahani-Asl: University of Ottawa
Hamed S. Najafabadi: McGill University, 3640 rue University
Vahab D. Soleimani: McGill University, 3640 rue University

Nature Communications, 2023, vol. 14, issue 1, 1-16

Abstract: Abstract Adult stem cells are indispensable for tissue regeneration, but their function declines with age. The niche environment in which the stem cells reside plays a critical role in their function. However, quantification of the niche effect on stem cell function is lacking. Using muscle stem cells (MuSC) as a model, we show that aging leads to a significant transcriptomic shift in their subpopulations accompanied by locus-specific gain and loss of chromatin accessibility and DNA methylation. By combining in vivo MuSC transplantation and computational methods, we show that the expression of approximately half of all age-altered genes in MuSCs from aged male mice can be restored by exposure to a young niche environment. While there is a correlation between gene reversibility and epigenetic alterations, restoration of gene expression occurs primarily at the level of transcription. The stem cell niche environment therefore represents an important therapeutic target to enhance tissue regeneration in aging.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-36265-x Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36265-x

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-36265-x

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().