Genome-wide host-pathogen analyses reveal genetic interaction points in tuberculosis disease

Jody Phelan, Paula Josefina Gomez-Gonzalez, Nuria Andreu, Yosuke Omae, Licht Toyo-Oka, Hideki Yanai, Reiko Miyahara, Supalert Nedsuwan, Paola Florez Sessions, Susana Campino, Neneh Sallah, Julian Parkhill, Nat Smittipat, Prasit Palittapongarnpim, Taisei Mushiroda, Michiaki Kubo, Katsushi Tokunaga, Surakameth Mahasirimongkol, Martin L. Hibberd () and Taane G. Clark ()
Additional contact information
Jody Phelan: London School of Hygiene and Tropical Medicine
Paula Josefina Gomez-Gonzalez: London School of Hygiene and Tropical Medicine
Nuria Andreu: London School of Hygiene and Tropical Medicine
Yosuke Omae: The University of Tokyo
Licht Toyo-Oka: The University of Tokyo
Hideki Yanai: Japan Anti-Tuberculosis Association
Reiko Miyahara: National Center for Global Health and Medicine
Supalert Nedsuwan: Chiangrai Prachanukroh Hospital
Paola Florez Sessions: Genome Institute of Singapore
Susana Campino: London School of Hygiene and Tropical Medicine
Neneh Sallah: London School of Hygiene and Tropical Medicine
Julian Parkhill: University of Cambridge
Nat Smittipat: National Science and Technology Development Agency
Prasit Palittapongarnpim: National Science and Technology Development Agency
Taisei Mushiroda: RIKEN Center for Integrative Medical Sciences
Michiaki Kubo: RIKEN Center for Integrative Medical Sciences
Katsushi Tokunaga: The University of Tokyo
Surakameth Mahasirimongkol: Ministry of Public Health
Martin L. Hibberd: London School of Hygiene and Tropical Medicine
Taane G. Clark: London School of Hygiene and Tropical Medicine

Nature Communications, 2023, vol. 14, issue 1, 1-7

Abstract: Abstract The genetics underlying tuberculosis (TB) pathophysiology are poorly understood. Human genome-wide association studies have failed so far to reveal reproducible susceptibility loci, attributed in part to the influence of the underlying Mycobacterium tuberculosis (Mtb) bacterial genotype on the outcome of the infection. Several studies have found associations of human genetic polymorphisms with Mtb phylo-lineages, but studies analysing genome-genome interactions are needed. By implementing a phylogenetic tree-based Mtb-to-human analysis for 714 TB patients from Thailand, we identify eight putative genetic interaction points (P

Date: 2023
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DOI: 10.1038/s41467-023-36282-w

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