Achiral organoiodine-functionalized helical polyisocyanides for multiple asymmetric dearomative oxidations

Zong-Quan Wu (), Xue Song, Yan-Xiang Li, Li Zhou, Yuan-Yuan Zhu, Zheng Chen and Na Liu
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Zong-Quan Wu: Jilin University
Xue Song: Hefei University of Technology
Yan-Xiang Li: Hefei University of Technology
Li Zhou: Hefei University of Technology
Yuan-Yuan Zhu: Hefei University of Technology
Zheng Chen: Jilin University
Na Liu: Jilin University

Nature Communications, 2023, vol. 14, issue 1, 1-11

Abstract: Abstract Immobilizing organocatalyst onto helical polymers not only facilitates the catalyst recycling from homogeneous reactions, but also boosts enantioselectivity. In this work, achiral organoiodine-functionalized single left- and right-handed helical polyisocyanides were prepared from the same monomers, which catalyzed three asymmetric oxidations gave the desired products in high yields and excellent enantioselectivity. The enantiomeric excess of the target products was up to 95%. Remarkably, the enantioselectivity can be switched by reversing the helicity of the polymer backbone. The polymer catalysts can be facilely recovered and recycled in different asymmetric oxidations with maintained excellent activity and enantioselectivity.

Date: 2023
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DOI: 10.1038/s41467-023-36327-0

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