Segmental motor recovery after cervical spinal cord injury relates to density and integrity of corticospinal tract projections

Gustavo Balbinot (), Guijin Li, Sukhvinder Kalsi-Ryan, Rainer Abel, Doris Maier, Yorck-Bernhard Kalke, Norbert Weidner, Rüdiger Rupp, Martin Schubert, Armin Curt and Jose Zariffa ()
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Gustavo Balbinot: Toronto Rehabilitation Institute, University Health Network
Guijin Li: Toronto Rehabilitation Institute, University Health Network
Sukhvinder Kalsi-Ryan: Toronto Rehabilitation Institute, University Health Network
Rainer Abel: Hohe Warte Bayreuth
Doris Maier: BG-Trauma Center
Yorck-Bernhard Kalke: RKU Universitäts- und Rehabilitationskliniken Ulm
Norbert Weidner: Heidelberg University Hospital
Rüdiger Rupp: Heidelberg University Hospital
Martin Schubert: Balgrist University Hospital
Armin Curt: Balgrist University Hospital
Jose Zariffa: Toronto Rehabilitation Institute, University Health Network

Nature Communications, 2023, vol. 14, issue 1, 1-16

Abstract: Abstract Cervical spinal cord injury (SCI) causes extensive impairments for individuals which may include dextrous hand function. Although prior work has focused on the recovery at the person-level, the factors determining the recovery of individual muscles are poorly understood. Here, we investigate the muscle-specific recovery after cervical spinal cord injury in a retrospective analysis of 748 individuals from the European Multicenter Study about Spinal Cord Injury (NCT01571531). We show associations between corticospinal tract (CST) sparing and upper extremity recovery in SCI, which improves the prediction of hand muscle strength recovery. Our findings suggest that assessment strategies for muscle-specific motor recovery in acute spinal cord injury are improved by accounting for CST sparing, and complement person-level predictions.

Date: 2023
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DOI: 10.1038/s41467-023-36390-7

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