Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots

Clara Albiñana, Zhihong Zhu, Nis Borbye-Lorenzen, Sanne Grundvad Boelt, Arieh S. Cohen, Kristin Skogstrand, Naomi R. Wray, Joana A. Revez, Florian Privé, Liselotte V. Petersen, Cynthia M. Bulik, Oleguer Plana-Ripoll, Katherine L. Musliner, Esben Agerbo, Anders D. Børglum, David M. Hougaard, Merete Nordentoft, Thomas Werge, Preben Bo Mortensen, Bjarni J. Vilhjálmsson and John J. McGrath ()
Additional contact information
Clara Albiñana: Aarhus University
Zhihong Zhu: Aarhus University
Nis Borbye-Lorenzen: Statens Serum Institut
Sanne Grundvad Boelt: Statens Serum Institut
Arieh S. Cohen: Testcenter Denmark, Statens Serum Institut
Kristin Skogstrand: Statens Serum Institut
Naomi R. Wray: University of Queensland
Joana A. Revez: University of Queensland
Florian Privé: Aarhus University
Liselotte V. Petersen: Aarhus University
Cynthia M. Bulik: University of North Carolina at Chapel Hill
Oleguer Plana-Ripoll: Aarhus University
Katherine L. Musliner: Aarhus University and Aarhus University Hospital-Psychiatry
Esben Agerbo: Aarhus University
Anders D. Børglum: The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
David M. Hougaard: The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
Merete Nordentoft: The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
Thomas Werge: The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
Preben Bo Mortensen: Aarhus University
Bjarni J. Vilhjálmsson: Aarhus University
John J. McGrath: Aarhus University

Nature Communications, 2023, vol. 14, issue 1, 1-16

Abstract: Abstract The vitamin D binding protein (DBP), encoded by the group-specific component (GC) gene, is a component of the vitamin D system. In a genome-wide association study of DBP concentration in 65,589 neonates we identify 26 independent loci, 17 of which are in or close to the GC gene, with fine-mapping identifying 2 missense variants on chromosomes 12 and 17 (within SH2B3 and GSDMA, respectively). When adjusted for GC haplotypes, we find 15 independent loci distributed over 10 chromosomes. Mendelian randomization analyses identify a unidirectional effect of higher DBP concentration and (a) higher 25-hydroxyvitamin D concentration, and (b) a reduced risk of multiple sclerosis and rheumatoid arthritis. A phenome-wide association study confirms that higher DBP concentration is associated with a reduced risk of vitamin D deficiency. Our findings provide valuable insights into the influence of DBP on vitamin D status and a range of health outcomes.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-36392-5 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36392-5

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-36392-5

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().