A single-cell transcriptional atlas reveals resident progenitor cell niche functions in TMJ disc development and injury

Ruiye Bi, Qing Yin, Haohan Li, Xianni Yang, Yiru Wang, Qianli Li, Han Fang, Peiran Li, Ping Lyu, Yi Fan, Binbin Ying and Songsong Zhu ()
Additional contact information
Ruiye Bi: Sichuan University
Qing Yin: Sichuan University
Haohan Li: Sichuan University
Xianni Yang: Sichuan University
Yiru Wang: Sichuan University
Qianli Li: Sichuan University
Han Fang: Sichuan University
Peiran Li: Sichuan University
Ping Lyu: Sichuan University
Yi Fan: Sichuan University
Binbin Ying: Ningbo First Hospital
Songsong Zhu: Sichuan University

Nature Communications, 2023, vol. 14, issue 1, 1-18

Abstract: Abstract The biological characteristics of the temporomandibular joint disc involve complex cellular network in cell identity and extracellular matrix composition to modulate jaw function. The lack of a detailed characterization of the network severely limits the development of targeted therapies for temporomandibular joint-related diseases. Here we profiled single-cell transcriptomes of disc cells from mice at different postnatal stages, finding that the fibroblast population could be divided into chondrogenic and non-chondrogenic clusters. We also find that the resident mural cell population is the source of disc progenitors, characterized by ubiquitously active expression of the NOTCH3 and THY1 pathways. Lineage tracing reveals that Myh11+ mural cells coordinate angiogenesis during disc injury but lost their progenitor characteristics and ultimately become Sfrp2+ non-chondrogenic fibroblasts instead of Chad+ chondrogenic fibroblasts. Overall, we reveal multiple insights into the coordinated development of disc cells and are the first to describe the resident mural cell progenitor during disc injury.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-36406-2 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36406-2

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-36406-2

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().